Converging mechanisms in ALS and FTD: disrupted RNA and protein homeostasis

SC Ling, M Polymenidou, DW Cleveland - Neuron, 2013 - cell.com
Breakthrough discoveries identifying common genetic causes for amyotrophic lateral
sclerosis (ALS) and frontotemporal dementia (FTD) have transformed our view of these …

Alzheimer's disease and vascular dementia in developing countries: prevalence, management, and risk factors

RN Kalaria, GE Maestre, R Arizaga… - The Lancet …, 2008 - thelancet.com
Despite mortality due to communicable diseases, poverty, and human conflicts, dementia
incidence is destined to increase in the developing world in tandem with the ageing …

Dementia in Africa: Current evidence, knowledge gaps, and future directions

RO Akinyemi, J Yaria, A Ojagbemi… - Alzheimer's & …, 2022 - Wiley Online Library
In tandem with the ever‐increasing aging population in low and middle‐income countries,
the burden of dementia is rising on the African continent. Dementia prevalence varies from …

FTD and ALS: a tale of two diseases

R Ferrari, D Kapogiannis, ED Huey… - Current Alzheimer …, 2011 - ingentaconnect.com
The first reports of disorders that in terms of cognitive and behavioral symptoms resemble
frontotemporal dementia (FTD) and in terms of motor symptoms resemble amyotrophic …

Genetics of FTLD: overview and what else we can expect from genetic studies

C Pottier, TA Ravenscroft… - Journal of …, 2016 - Wiley Online Library
Frontotemporal lobar degeneration (FTLD) comprises a highly heterogeneous group of
disorders clinically associated with behavioral and personality changes, language …

Disruption of endocytic trafficking in frontotemporal dementia with CHMP2B mutations

H Urwin, A Authier, JE Nielsen, D Metcalf… - Human molecular …, 2010 - academic.oup.com
Mutations in CHMP2B cause frontotemporal dementia (FTD) in a large Danish pedigree,
which is termed FTD linked to chromosome 3 (FTD-3), and also in an unrelated familial FTD …

CHMP2B C-truncating mutations in frontotemporal lobar degeneration are associated with an aberrant endosomal phenotype in vitro

J van der Zee, H Urwin, S Engelborghs… - Human molecular …, 2008 - academic.oup.com
The charged multivesicular body protein 2B gene (CHMP2B) was recently associated with
frontotemporal lobar degeneration (FTLD) linked to chromosome 3 in a Danish FTLD family …

Novel splicing mutation in the progranulin gene causing familial corticobasal syndrome

M Masellis, P Momeni, W Meschino, R Heffner Jr… - Brain, 2006 - academic.oup.com
Corticobasal syndrome (CBS) is a rare cognitive and movement disorder characterized by
asymmetric rigidity, apraxia, alien-limb phenomenon, cortical sensory loss, myoclonus, focal …

Overriding FUS autoregulation in mice triggers gain-of-toxic dysfunctions in RNA metabolism and autophagy-lysosome axis

SC Ling, SG Dastidar, S Tokunaga, WY Ho, K Lim… - elife, 2019 - elifesciences.org
Mutations in coding and non-coding regions of FUS cause amyotrophic lateral sclerosis
(ALS). The latter mutations may exert toxicity by increasing FUS accumulation. We show …

Synaptic paths to neurodegeneration: the emerging role of TDP‐43 and FUS in synaptic functions

SC Ling - Neural Plasticity, 2018 - Wiley Online Library
TAR DNA‐binding protein‐43 KDa (TDP‐43) and fused in sarcoma (FUS) as the defining
pathological hallmarks for amyotrophic lateral sclerosis (ALS) and frontotemporal dementia …