[HTML][HTML] The gut microbiome in Alzheimer's disease: what we know and what remains to be explored
Abstract Alzheimer's disease (AD), the most common cause of dementia, results in a
sustained decline in cognition. There are currently few effective disease modifying therapies …
sustained decline in cognition. There are currently few effective disease modifying therapies …
[HTML][HTML] Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer's disease
Alzheimer's disease (AD) is the most common neurodegenerative disorder seen in age-
dependent dementia. There is currently no effective treatment for AD, which may be …
dependent dementia. There is currently no effective treatment for AD, which may be …
Sleep deprivation and neurological disorders
Sleep plays an important role in maintaining neuronal circuitry, signalling and helps
maintain overall health and wellbeing. Sleep deprivation (SD) disturbs the circadian …
maintain overall health and wellbeing. Sleep deprivation (SD) disturbs the circadian …
Association between circadian rhythms and neurodegenerative diseases
Dysfunction in 24-h circadian rhythms is a common occurrence in ageing adults; however,
circadian rhythm disruptions are more severe in people with age-related neurodegenerative …
circadian rhythm disruptions are more severe in people with age-related neurodegenerative …
β-Amyloid accumulation in the human brain after one night of sleep deprivation
The effects of acute sleep deprivation on β-amyloid (Aβ) clearance in the human brain have
not been documented. Here we used PET and 18F-florbetaben to measure brain Aβ burden …
not been documented. Here we used PET and 18F-florbetaben to measure brain Aβ burden …
Slow wave sleep disruption increases cerebrospinal fluid amyloid-β levels
YES Ju, SJ Ooms, C Sutphen, SL Macauley… - Brain, 2017 - academic.oup.com
See Mander et al.(doi: 10.1093/awx174) for a scientific commentary on this article. Sleep
deprivation increases amyloid-β, suggesting that chronically disrupted sleep may promote …
deprivation increases amyloid-β, suggesting that chronically disrupted sleep may promote …
Mechanisms linking circadian clocks, sleep, and neurodegeneration
ES Musiek, DM Holtzman - Science, 2016 - science.org
Disruptions of normal circadian rhythms and sleep cycles are consequences of aging and
can profoundly affect health. Accumulating evidence indicates that circadian and sleep …
can profoundly affect health. Accumulating evidence indicates that circadian and sleep …
Circadian rest-activity pattern changes in aging and preclinical Alzheimer disease
ES Musiek, M Bhimasani, MA Zangrilli… - JAMA …, 2018 - jamanetwork.com
Importance Circadian rhythm disturbances occur in symptomatic Alzheimer disease (AD)
and have been hypothesized to contribute to disease pathogenesis. However, it is unknown …
and have been hypothesized to contribute to disease pathogenesis. However, it is unknown …
Sleep, cognition, and normal aging: integrating a half century of multidisciplinary research
MK Scullin, DL Bliwise - Perspectives on Psychological …, 2015 - journals.sagepub.com
Sleep is implicated in cognitive functioning in young adults. With increasing age, there are
substantial changes to sleep quantity and quality, including changes to slow-wave sleep …
substantial changes to sleep quantity and quality, including changes to slow-wave sleep …
[HTML][HTML] Sleep, circadian rhythms, and the pathogenesis of Alzheimer disease
Disturbances in the sleep–wake cycle and circadian rhythms are common symptoms of
Alzheimer Disease (AD), and they have generally been considered as late consequences of …
Alzheimer Disease (AD), and they have generally been considered as late consequences of …