Chronic pain conditions are multifactorial disorders with a high frequency in the population.
Their pathophysiology is often unclear, and treatment is inefficient. During the last 20 years …

In the last 30 years dopamine has been considered as playing a role in the pathogenesis of
migraine. The literature indicates that migraineurs are hypersensitive to dopamine agonists …

With an increased emphasis on genotyping of single nucleotide polymorphisms (SNPs) in
disease association studies, the genotyping platform of choice is constantly evolving. In …

Migraine is a complex neurovascular disorder with substantial evidence supporting a
genetic contribution. Prior attempts to localize susceptibility loci for common forms of …

Several cellular and molecular mechanisms have been implicated in migraine
pathophysiology including abnormal neuronal excitability and vascular events. Drugs from …

Large individual differences in the clinical response to morphine therapy have been known
for a long time by clinicians. The recent advances in genomic research encourage the …

Abstract Background The C677T variant in the methylenetetrahydrofolate reductase
(MTHFR) gene is associated with increased levels of circulating homocysteine and is a mild …

Dopamine beta-hydroxylase (DBH) deficiency is a genetic disorder in which affected
patients cannot synthesize norepinephrine, epinephrine, and octopamine in either the …

Our understanding of migraine pathophysiology is a work in progress. As more is learned
about migraine, it seems that the probability of identifying a single unifying explanation for …

Migraine is a common neurological disorder with a genetically complex background. This
paper describes a meta-analysis of genome-wide association (GWA) studies on migraine …