Lineage plasticity, a process whereby cells change their phenotype to take on a different
molecular and/or histologic identity, is a key driver of cancer progression and therapy …

Pancreatic Ductal Adenocarcinoma (PDAC) is the fourth most common cause of cancer-
related death and is the most lethal of common malignancies with a five-year survival rate …

Pancreatic ductal adenocarcinoma (PDAC) has a dismal prognosis largely owing to
inefficient diagnosis and tenacious drug resistance. Activation of pancreatic stellate cells …

Abstract Background Circulating tumor cells (CTCs) are responsible for the metastatic
dissemination of colorectal cancer (CRC) to the liver, lungs and lymph nodes. CTCs rarity …

Background & Aims Oncogenic Kirsten Rat Sarcoma virus (KRAS) is the hallmark mutation
of human pancreatic cancer and a driver of tumorigenesis in genetically engineered mouse …

Pancreatic adenocarcinoma is a malignancy with rising incidence and grim prognosis.
Despite improvements in therapeutics for treating metastatic pancreatic cancer, this disease …

β-Cell replacement by in situ reprogramming of non-β-cells is a promising diabetes therapy.
Following the observation that near-total β-cell ablation in adult mice triggers the …

Abstract MicroRNA-29 (miR-29) is a critical regulator of fibroinflammatory processes in
human diseases. In this study, we found a decrease in miR-29a in experimental and human …

Pancreatic cancer (PC) is the deadliest neoplastic epithelial malignancies and is projected
to be the second leading cause of cancer-related mortality by 2024. Five years overall …

Diabetes mellitus (DM) is a chronic condition characterised by β cell dysfunction and
persistent hyperglycaemia. The disorder can be due to the absence of adequate pancreatic …