Repair of bulky DNA adducts by the nucleotide excision repair (NER) pathway is one of the
more versatile DNA repair pathways for the removal of DNA lesions. There are two subsets …

Various DNA alterations can be caused by exposure to environmental and endogenous
carcinogens. Most of these alterations, if not repaired, can result in genetic instability …

Lung cancer is a leading cause of cancer mortality with an inter-individual difference in
susceptibility to the disease. The inheritance of low-efficiency genotypes involved in DNA …

Air pollution represents a considerable threat to health worldwide. The São Paulo
Metropolitan area, in Brazil, has a unique composition of atmospheric pollutants with a …

DNA repair genes play an important role in maintaining stability and integrity of genomic
DNA. Polymorphisms in nucleotide excision repair genes may cause variations in DNA …

Background Polymorphisms in DNA repair genes have been associated to repair DNA
lesions, and might contribute to the individual susceptibility to develop different types of …

Cisplatin, carboplatin and oxaliplatin are some of the most widely used anti-cancer agents in
solid tumours. The cytotoxicity of platinating agents is directly related to their ability to cause …

DNA repair function is believed to play an important role in cancer development and to be
affected by genetic polymorphisms. Numerous epidemiological studies have examined the …

Lung cancer is one of the most common and deadliest cancers in the world. The major socio-
environmental risk factor involved in the development of lung cancer is cigarette smoking …

Background. Xeroderma pigmentosum (XP) is a rare autosomal recessive disorder of UV
radiation‐induced damage repair that is characterized by photosensitivity and a propensity …