Application of patient-specific computational fluid dynamics in coronary and intra-cardiac flow simulations: Challenges and opportunities
The emergence of new cardiac diagnostics and therapeutics of the heart has given rise to
the challenging field of virtual design and testing of technologies in a patient-specific …
the challenging field of virtual design and testing of technologies in a patient-specific …
Computational medicine: translating models to clinical care
RL Winslow, N Trayanova, D Geman… - Science translational …, 2012 - science.org
Because of the inherent complexity of coupled nonlinear biological systems, the
development of computational models is necessary for achieving a quantitative …
development of computational models is necessary for achieving a quantitative …
[HTML][HTML] A comprehensive and biophysically detailed computational model of the whole human heart electromechanics
While ventricular electromechanics is extensively studied in both physiological and
pathological conditions, four-chamber heart models have only been addressed recently; …
pathological conditions, four-chamber heart models have only been addressed recently; …
Integrated heart—coupling multiscale and multiphysics models for the simulation of the cardiac function
Mathematical modeling of the human heart and its function can expand our understanding of
various cardiac diseases, which remain the most common cause of death in the developed …
various cardiac diseases, which remain the most common cause of death in the developed …
[HTML][HTML] Electro-mechanical whole-heart digital twins: a fully coupled multi-physics approach
T Gerach, S Schuler, J Fröhlich, L Lindner… - Mathematics, 2021 - mdpi.com
Mathematical models of the human heart are evolving to become a cornerstone of precision
medicine and support clinical decision making by providing a powerful tool to understand …
medicine and support clinical decision making by providing a powerful tool to understand …
[图书][B] Mathematical modelling of the human cardiovascular system: data, numerical approximation, clinical applications
Mathematical and numerical modelling of the human cardiovascular system has attracted
remarkable research interest due to its intrinsic mathematical difficulty and the increasing …
remarkable research interest due to its intrinsic mathematical difficulty and the increasing …
Polygonal surface processing and mesh generation tools for the numerical simulation of the cardiac function
M Fedele, A Quarteroni - International Journal for Numerical …, 2021 - Wiley Online Library
In order to simulate the cardiac function for a patient‐specific geometry, the generation of the
computational mesh is crucially important. In practice, the input is typically a set of …
computational mesh is crucially important. In practice, the input is typically a set of …
Fully coupled fluid‐electro‐mechanical model of the human heart for supercomputers
A Santiago, J Aguado‐Sierra… - … journal for numerical …, 2018 - Wiley Online Library
In this work, we present a fully coupled fluid‐electro‐mechanical model of a 50th percentile
human heart. The model is implemented on Alya, the BSC multi‐physics parallel code …
human heart. The model is implemented on Alya, the BSC multi‐physics parallel code …
Surrogate models based on machine learning methods for parameter estimation of left ventricular myocardium
L Cai, L Ren, Y Wang, W Xie… - Royal Society open …, 2021 - royalsocietypublishing.org
A long-standing problem at the frontier of biomechanical studies is to develop fast methods
capable of estimating material properties from clinical data. In this paper, we have studied …
capable of estimating material properties from clinical data. In this paper, we have studied …
Biophysically detailed mathematical models of multiscale cardiac active mechanics
We propose four novel mathematical models, describing the microscopic mechanisms of
force generation in the cardiac muscle tissue, which are suitable for multiscale numerical …
force generation in the cardiac muscle tissue, which are suitable for multiscale numerical …