Axons are the slender, cable-like, up to meter-long projections of neurons that electrically
wire our brains and bodies. In spite of their challenging morphology, they usually need to be …

Axons are the cable-like protrusions of neurons which wire up the nervous system. Polar
bundles of microtubules (MTs) constitute their structural backbones and are highways for life …

Spectraplakins are evolutionarily well conserved cytoskeletal linker molecules that are true
members of three protein families: plakins, spectrins and Gas2-like proteins. Spectraplakin …

Aberrant expression of the Spectraplakin Dystonin (DST) has been observed in various
cancers, including those of the breast. However, little is known about its role in …

A single species of fly, Drosophila melanogaster, has been the subject of scientific research
for more than one hundred years. Why does this tiny insect merit such intense scrutiny …

Subcellular lumen formation by single-cells involves complex cytoskeletal remodelling. We
have previously shown that centrosomes are key players in the initiation of subcellular …

Dorsal closure of the Drosophila embryonic epithelium provides an excellent model system
for the in vivo analysis of molecular mechanisms regulating cytoskeletal rearrangements. In …

The spectraplakin family of proteins includes ACF7/MACF1 and BPAG1/dystonin in
mammals, VAB-10 in Caenorhabditis elegans, Magellan in zebrafish, and Short stop (Shot) …

The use of primary neuronal cultures generated from Drosophila tissue provides a powerful
model for studies of transport mechanisms. Cultured fly neurons provide similarly detailed …

Axons are the long and slender processes of neurons constituting the biological cables that
wire the nervous system. The growth and maintenance of axons require loose microtubule …