Blood vessels in the central nervous system (CNS) are unique in having high electrical
resistance and low permeability, which creates a selective barrier protecting sensitive neural …

Laminin, a major component of the basal lamina (BL), is a heterotrimeric protein with many
isoforms. In the CNS, laminin is expressed by almost all cell types, yet different cells …

Endothelial cells of blood vessels of the central nervous system (CNS) constitute blood-CNS
barriers. Barrier properties are not intrinsic to these cells; rather they are induced and …

In a recent study of young mice, we showed that chronic mild hypoxia (CMH, 8% O2) triggers
transient blood–brain barrier (BBB) disruption, and that microglia play an important vasculo …

Background Chronic mild hypoxia (CMH, 8% O 2) stimulates robust vascular remodelling in
the brain, but it also triggers transient vascular disruption. This raises the fundamental …

We previously demonstrated that cross-talk between α5β1 integrin and the angiopoietin-1
(Ang1)/Tie2 receptor plays an important role in regulating brain endothelial angiogenic …

While several studies have shown that hypoxic preconditioning suppresses development of
the experimental autoimmune encephalomyelitis (EAE) model of multiple sclerosis (MS), no …

Integrin-dependent crosstalk between cell-matrix adhesions and cell-cell junctions is critical
for controlling endothelial permeability and proliferation in cancer and inflammatory …

Integrins are heterodimeric membrane proteins expressed on the surface of most cells. They
mediate adhesion and signaling processes relevant for a wealth of physiological processes …

Abstract γ-bungarotoxin (γ-BGT) is an RGD motif-containing protein, derived from the venom
of Bungarus multicinctus, leading to acute death in mice. These RGD motif-containing …