The extracellular matrix as a multitasking player in disease
Extracellular matrices (ECM s) are highly specialized and dynamic three‐dimensional (3D)
scaffolds into which cells reside in tissues. ECM is composed of a variety of fibrillar …
scaffolds into which cells reside in tissues. ECM is composed of a variety of fibrillar …
The nature and biology of basement membranes
A Pozzi, PD Yurchenco, RV Iozzo - Matrix Biology, 2017 - Elsevier
Basement membranes are delicate, nanoscale and pliable sheets of extracellular matrices
that often act as linings or partitions in organisms. Previously considered as passive …
that often act as linings or partitions in organisms. Previously considered as passive …
[HTML][HTML] From structure to phenotype: impact of collagen alterations on human health
L Arseni, A Lombardi, D Orioli - International journal of molecular sciences, 2018 - mdpi.com
The extracellular matrix (ECM) is a highly dynamic and heterogeneous structure that plays
multiple roles in living organisms. Its integrity and homeostasis are crucial for normal tissue …
multiple roles in living organisms. Its integrity and homeostasis are crucial for normal tissue …
Fxr signaling and microbial metabolism of bile salts in the zebrafish intestine
Bile salt synthesis, secretion into the intestinal lumen, and resorption in the ileum occur in all
vertebrate classes. In mammals, bile salt composition is determined by host and microbial …
vertebrate classes. In mammals, bile salt composition is determined by host and microbial …
Code inside the codon: the role of synonymous mutations in regulating splicing machinery and its impact on disease
In eukaryotes, precise pre-mRNA processing, including alternative splicing, is essential to
carry out the intricate protein translation process. Both point mutations (that alter the …
carry out the intricate protein translation process. Both point mutations (that alter the …
Challenges and strategies for the delivery of biologics to the cornea
M Wels, D Roels, K Raemdonck, SC De Smedt… - Journal of Controlled …, 2021 - Elsevier
Biologics, like peptides, proteins and nucleic acids, have proven to be promising drugs for
the treatment of numerous diseases. However, besides the off label use of the monoclonal …
the treatment of numerous diseases. However, besides the off label use of the monoclonal …
[HTML][HTML] Zebrafish model in ophthalmology to study disease mechanism and drug discovery
Y Hong, Y Luo - Pharmaceuticals, 2021 - mdpi.com
Visual impairment and blindness are common and seriously affect people's work and quality
of life in the world. Therefore, the effective therapies for eye diseases are of high priority …
of life in the world. Therefore, the effective therapies for eye diseases are of high priority …
[HTML][HTML] Corneal epithelial regeneration: old and new perspectives
A Nuzzi, F Pozzo Giuffrida, S Luccarelli… - International Journal of …, 2022 - mdpi.com
Corneal blindness is the fifth leading cause of blindness worldwide, and therapeutic options
are still often limited to corneal transplantation. The corneal epithelium has a strong barrier …
are still often limited to corneal transplantation. The corneal epithelium has a strong barrier …
[HTML][HTML] An overview towards zebrafish larvae as a model for ocular diseases
Despite the obvious morphological differences in the visual system, zebrafish share a similar
architecture and components of the same embryonic origin as humans. The zebrafish retina …
architecture and components of the same embryonic origin as humans. The zebrafish retina …
[HTML][HTML] Effect of Polydeoxyribonucleotide (PDRN) Treatment on Corneal Wound Healing in Zebrafish (Danio rerio)
This study aimed to develop a corneal epithelial injury model in zebrafish (Danio rerio) and
investigate the effectiveness of polydeoxyribonucleotide (PDRN) treatment on in vivo …
investigate the effectiveness of polydeoxyribonucleotide (PDRN) treatment on in vivo …