Wnt signaling determines major developmental processes in the embryonic state and
regulates maintenance, self-renewal and differentiation of adult mammalian tissue stem …

Schizophrenia (SCZ) and major depressive disorder (MDD) in treatment‐naive patients are
associated with increased risk for type 2 diabetes (T2D) and metabolic syndrome (MetS) …

Genome-wide association studies (GWASs) have identified numerous loci that influence risk
for psychiatric diseases. Genetically engineered mice are often used to characterize genes …

Canonical Wnt signaling, which is transduced by β‐catenin and lymphoid enhancer factor
1/T cell‐specific transcription factors (LEF1/TCFs), regulates many aspects of metazoan …

Schizophrenia is associated with increased risk for type 2 diabetes mellitus, resulting in
elevated cardiovascular risk and limited life expectancy, translated into a weighted average …

Objective Acquiring a diagnosis of schizophrenia reduces life expectancy for many reasons
including poverty, difficulties in communication, side‐effects of medication and access to …

People with schizophrenia have 2-to 5-fold higher risk of type 2 diabetes than the general
population. The traditional risk factors for type 2 diabetes, especially obesity, poor diet, and …

Background Schizophrenia (SCZ) and type 2 diabetes mellitus (T2D) are both complex
diseases. Accumulated studies indicate that schizophrenia patients are prone to present the …

Wnt/β-catenin pathway, the effectors of which are transcription factors of the LEF1/TCF
family, is primarily associated with development. Strikingly, however, some of the genes of …

The TCF7L2 protein is a key transcriptional effector of the Wnt/β‐catenin signaling pathway,
regulating gene expression. It was initially identified in cancer research and embryologic …