The sirtuin family of nicotinamide adenine dinucleotide–dependent deacylases (SIRT1–7)
are thought to be responsible, in large part, for the cardiometabolic benefits of lean diets and …

Nicotinamide adenine dinucleotide (NAD+) is a central metabolite involved in energy and
redox homeostasis as well as in DNA repair and protein deacetylation reactions …

Neutrophil extracellular traps expelled from suicidal neutrophils comprise a complex
structure of nuclear chromatin and proteins of nuclear, granular, and cytosolic origin. These …

The chemokine receptor CXCR2 and its ligands are implicated in the progression of tumours
and various inflammatory diseases. Activation of the CXCLs/CXCR2 axis activates multiple …

Neutrophils are the most abundant, short lived, and terminally differentiated leukocytes with
distinct tiers of arsenals to counter pathogens. Neutrophils were traditionally considered …

Characterized by a surplus of whole-body adiposity, obesity is strongly associated with the
prognosis of atherosclerosis, a hallmark of coronary artery disease (CAD) and the major …

Infiltration of leukocyte subsets is a driving force of atherosclerotic lesion growth, and during
the past decade, neutrophils have received growing attention in chronic inflammatory …

Atherosclerosis is the leading cause of death worldwide and leukocyte recruitment is a key
element of this phenomenon, thus allowing immune cells to enter the arterial wall. There, in …

Nicotinamide phosphoribosyltransferase (NAMPT) is the bottleneck enzyme of the NAD
salvage pathway and thereby is a controller of intracellular NAD concentrations. It has been …

Neutrophils are the most numerous cells in the leukocyte population and essential for innate
immunity. To limit their effector functions, neutrophils are able to modulate glycolysis and …