Parkinson's disease (PD) is a neurodegenerative disorder for which a greater prevalence
and incidence is described in men. This suggests a protective effect of sex hormones in the …

Stroke and traumatic injuries of the brain and spinal cord are major public health issues. In
the last few decades, hundreds of clinical trials with patients suffering from these conditions …

Rationale Preclinical and clinical data suggest that pregnenolone may be a promising
therapeutic in schizophrenia. Pregnenolone is neuroprotective and enhances learning and …

Co-treatment of neuroprotective reagents may improve the therapeutic efficacy of
hypothermia in protecting neurons during ischemic stroke. This study aimed to find …

Background: Numerous studies have reported on the neuroprotective activity of estradiol,
whereas the effect of the other ovarian steroid, progesterone, is much less documented …

Increasing evidence shows that progesterone, a neuroactive steroid, has protective actions
in central nervous system, but there is little evidence to show the protective mechanism of …

Learning and memory deficits in Alzheimer's disease (AD) result from synaptic failure and
neuronal loss, the latter caused in part by excitotoxicity and oxidative stress. A therapeutic …

In this study, protective actions of the sex steroid hormones, progesterone, testosterone, and
17β-estradiol, against oxygen-glucose deprivation (OGD)/reoxygenation-induced neuronal …

The neuritogenic and neuroprotective activities of six starfish polar steroids, asterosaponin
Р1,(25 S)-5α-cholestane-3β, 4β, 6α, 7α, 8, 15α, 16β, 26-octaol, and (25 S)-5α-cholestane …

Background Organotypic hippocampal slice cultures (OHSCs) are an attractive in vitro
model to examine mechanisms of neuronal injury, because the normal hippocampal …