Juvenile myelomonocytic leukemia (JMML) is a unique, aggressive hematopoietic disorder
of infancy/early childhood caused by excessive proliferation of cells of monocytic and …

Myeloid neoplasms derive from the pathological clonal expansion of an abnormal stem cell
and span a diverse spectrum of phenotypes including acute myeloid leukaemia (AML) …

Oncogenic Ras mutations occur in various leukemias. It was unclear if, besides the direct
transforming effect via constant RAS/MEK/ERK signaling, an inflammation-related effect of …

Juvenile myelomonocytic leukemia (JMML) is an aggressive childhood myeloproliferative
disorder characterized by the overproduction of myelomonocytic cells. JMML incidence …

Juvenile myelomonocytic leukemia (JMML) is a rare pediatric leukemia characterized by
mutations in five canonical RAS pathway genes. The diagnosis is made by typical clinical …

Myelodysplastic syndromes (MDS) and the mixed myelodysplastic/myeloproliferative
disorder juvenile myelomonocytic leukaemia (JMML) are rare haematopoietic stem cell …

DNA methyltransferase-inhibiting azanucleosides have become a mainstay of treatment of
myeloid neoplasms in adult patients, 1 with 5-azacytidine (azacitidine) being the agent in …

In 1982, chronic myelomonocytic leukemia (CMML) was first classified in the category of
myelodysplastic syndromes (MDSs), but it always seemed somewhat out of place compared …

Aberrant DNA methylation contributes to the malignant phenotype in virtually all types of
cancer, including myeloid leukemia. We hypothesized that CpG island hypermethylation …

Juvenile myelomonocytic leukemia (JMML) is a rare pediatric myelodysplastic/
myeloproliferative neoplasm overlap disease. JMML is associated with mutations in the RAS …