Dysregulated Notch signaling has been implicated in numerous human diseases, including
a broad spectrum of cancers. Mutations in Notch1 are prevalent in T-cell acute lymphoblastic …

Proteins and small peptides (growth factors and hormones) are key molecules in
maintaining cellular homeostasis. To that end, Notch signaling pathway proteins are known …

Glioblastoma multiforme (GBM) is the most frequent and incurable type of brain tumor of
adults. Hypoxia has been shown to direct GBM toward a more aggressive and malignant …

BACKGROUND: The Notch signalling pathway is activated in a variety of malignancies and
has been implicated in colorectal cancer progression. One of the first steps in the Notch …

Ngn3 is recognized as a regulator of pancreatic endocrine formation, and Notch signaling as
an important negative regulator Ngn3 gene expression. By conditionally controlling …

Interactions between liver cells are closely regulated by Notch signaling. Notch signaling
has been reported clinically related to bile duct hypogenesis in Alagille syndrome, which is …

Background and purpose Patients with advanced NSCLC have survival rates< 15%. The
NOTCH pathway plays an important role during lung development and physiology but is …

Globally, hepatocellular carcinoma (HCC) is a leading cause of cancer and cancer-related
deaths. The therapeutic efficacy of locoregional and systemic treatment in patients with …

We previously demonstrated that expression of Notch-1 is associated with poor prognosis in
lung adenocarcinoma (LAD) patients. The aim of this study is to reveal whether Notch-1 was …

Background The microenvironment plays an important role in regulating tumor response to
radiotherapy. Ionizing radiation can disrupt tumor vasculature, and Notch pathway inhibition …