The uptake of calcium into and extrusion of calcium from the mitochondrial matrix is a
fundamental biological process that has critical effects on cellular metabolism, signaling …

Adult cardiomyocytes are postmitotic cells that undergo very limited cell division. Thus,
cardiomyocyte death as occurs during myocardial infarction has very detrimental …

In heart failure, alterations of Na+ and Ca2+ handling, energetic deficit, and oxidative stress
in cardiac myocytes are important pathophysiological hallmarks. Mitochondria are central to …

Mitochondrial permeability transition pore (MPTP) formation contributes to ischemia-
reperfusion injury in the heart and several degenerative diseases, including muscular …

Excessive production of mitochondrial reactive oxygen species (mROS) is strongly
associated with mitochondrial and cellular oxidative damage, aging, and degenerative …

Abstract Calcium (Ca 2+) signaling is critical for cell function and cell survival. Mitochondria
play a major role in regulating the intracellular Ca 2+ concentration ([Ca 2+] i). Mitochondrial …

Type 2 diabetic cardiomyopathy features Ca 2+ signaling abnormalities, notably an altered
mitochondrial Ca 2+ handling. We here aimed to study if it might be due to a dysregulation of …

Mitochondria vary in morphology and function in different tissues; however, little is known
about their molecular diversity among cell types. Here we engineered MitoTag mice, which …

Calcium ions are highly versatile intracellular signals that regulate many cellular processes.
The key to achieving this pleiotropic role is the spatiotemporal control of calcium …

The brain is one of the most energy-consuming organs in the mammalian body, and
synaptic transmission is one of the major contributors. To meet these energetic …