Differences in cardiac and aortic structure and function are associated with cardiovascular
diseases and a wide range of other types of disease. Here we analyzed cardiovascular …

SRY‐box transcription factor 2 (SOX2) overlapping transcript (SOX2‐OT) is an evolutionarily
conserved long noncoding RNA. Its intronic region contains the SOX2 gene, the major …

Substance use disorders commonly co-occur with one another and with other psychiatric
disorders. They share common features including high impulsivity, negative affect, and lower …

Synapses are interneuronal junctions which form neuronal networks and play roles in a
variety of functions, including learning and memory. Two types of junctions, synaptic …

Childhood maltreatment is highly prevalent and serves as a risk factor for mental and
physical disorders. Self-reported childhood maltreatment appears heritable, but the specific …

Background The origin of sex differences in prevalence and presentation of neuropsychiatric
and behavioral traits is largely unknown. Given established genetic contributions and …

Opioid craving and relapse vulnerability is associated with severe and persistent sleep and
circadian rhythm disruptions. Understanding the neurobiological underpinnings of circadian …

Importance Although hypothesis-driven research has identified several factors associated
with psychosis, this one-exposure-to-one-outcome approach fails to embrace the multiplicity …

Increased risk-taking is a central component of bipolar disorder (BIP) and is implicated in
schizophrenia (SCZ). Risky behaviours, including smoking and alcohol use, are …

CADM2 has been associated with a range of behavioural and metabolic traits, including
physical activity, risk-taking, educational attainment, alcohol and cannabis use and obesity …