Cellular uptake of nanoparticles versus small molecules: a matter of size

J Mosquera, I García… - Accounts of chemical …, 2018 - ACS Publications
Conspectus The primary function of the cell membrane is to protect cells from their
surroundings. This entails a strict regulation on controlling the exchange of matter between …

Combination of cell-penetrating peptides with nanoparticles for therapeutic application: a review

S Silva, AJ Almeida, N Vale - Biomolecules, 2019 - mdpi.com
Cell-penetrating peptides (CPPs), also known as protein translocation domains, membrane
translocating sequences or Trojan peptides, are small molecules of 6 to 30 amino acid …

Therapeutic targeting of non-coding RNAs in cancer

O Slaby, R Laga, O Sedlacek - Biochemical journal, 2017 - portlandpress.com
The majority of the human genome encodes RNAs that do not code for proteins. These non-
coding RNAs (ncRNAs) affect normal expression of the genes, including oncogenes and …

Production and clinical development of nanoparticles for gene delivery

J Chen, Z Guo, H Tian, X Chen - Molecular Therapy Methods & Clinical …, 2016 - cell.com
Gene therapy is a promising strategy for specific treatment of numerous gene-associated
human diseases by intentionally altering the gene expression in pathological cells. A …

Poly (lactic acid) nanoparticles and cell-penetrating peptide potentiate mRNA-based vaccine expression in dendritic cells triggering their activation

AL Coolen, C Lacroix, P Mercier-Gouy, E Delaune… - Biomaterials, 2019 - Elsevier
Messenger RNA-based vaccines have the potential to trigger robust cytotoxic immune
responses, which are essential for fighting cancer and infectious diseases like HIV. Dendritic …

Cell-penetrating peptides: strategies for anticancer treatment

D Raucher, JS Ryu - Trends in molecular medicine, 2015 - cell.com
Cell-penetrating peptides (CPP) provide an efficient strategy for the intracellular delivery of
bioactive molecules in various biomedical applications. This review focuses on recent …

Designing improved active peptides for therapeutic approaches against infectious diseases

B Gomes, MT Augusto, MR Felício, A Hollmann… - Biotechnology …, 2018 - Elsevier
Infectious diseases are one of the main causes of human morbidity and mortality. In the last
few decades, pathogenic microorganisms' resistance to conventional drugs has been …

[HTML][HTML] Cell penetrating peptides in preclinical and clinical cancer diagnosis and therapy

PP Tripathi, H Arami, I Banga, J Gupta, S Gandhi - Oncotarget, 2018 - ncbi.nlm.nih.gov
Delivery of imaging reagents and drugs to tumors is essential for cancer diagnosis and
therapy. In addition to therapeutic and diagnostic functionalities, peptides have potential …

Enzyme-triggered transcytosis of drug carrier system for deep penetration into hepatoma tumors

H Yan, P Xu, H Ma, Y Li, R Zhang, H Cong, B Yu… - Biomaterials, 2023 - Elsevier
In recent years, nano-drug delivery systems have made considerable progress in the
direction of tumor treatment, but the low permeability of drugs has restricted the development …

Peptide-based nanoassemblies in gene therapy and diagnosis: paving the way for clinical application

S Tarvirdipour, X Huang, V Mihali, CA Schoenenberger… - Molecules, 2020 - mdpi.com
Nanotechnology approaches play an important role in developing novel and efficient
carriers for biomedical applications. Peptides are particularly appealing to generate such …