DNA methylation is of paramount importance for mammalian embryonic development. DNA
methylation has numerous functions: it is implicated in the repression of transposons and …

Background DNA methylation is an epigenetic chromatin mark that allows heterochromatin
formation and gene silencing. It has a fundamental role in preserving genome stability …

Ten-eleven translocation (TET) proteins are iron-dependent and α-ketoglutarate-dependent
dioxygenases that sequentially oxidize the methyl group of 5-methylcytosine (5mC) to 5 …

Hematopoietic stem and progenitor cells (HSPCs) arise during embryonic development and
are essential for sustaining the blood and immune systems throughout life. Tight regulation …

Inflammatory signaling is required for hematopoietic stem and progenitor cell (HSPC)
development. Here, we studied the involvement of RIG-I-like receptors (RLRs) in HSPC …

Abstract HELLS/LSH (Helicase, Lymphoid Specific) is a SNF2-like chromatin remodelling
protein involved in DNA methylation. Its loss-of-function in humans causes humoral …

In order to maintain cell and organism homeostasis, the genetic material has to be faithfully
and equally inherited through cell divisions while preserving its integrity. Centromeres play …

DNA methylation is an epigenetic modification essential for normal mammalian
development. Initially associated with gene silencing, more diverse roles for DNA …

Tandemly repeated satellite DNAs are major components of centromeres and
pericentromeric heterochromatin which are crucial chromosomal elements responsible for …

The most fundamental region of the chromosome for maintaining accurate genome
segregation and stability is the centromeric chromatin [1, 2]. In this review, we will focus on …