Combating mosquito-borne diseases using genetic control technologies

GH Wang, S Gamez, RR Raban, JM Marshall… - Nature …, 2021 - nature.com
Mosquito-borne diseases, such as dengue and malaria, pose significant global health
burdens. Unfortunately, current control methods based on insecticides and environmental …

Wolbachia as translational science: controlling mosquito-borne pathogens

EP Caragata, HLC Dutra, PHF Sucupira… - Trends in …, 2021 - cell.com
In this review we examine how exploiting the Wolbachia–mosquito relationship has become
an increasingly popular strategy for controlling arbovirus transmission. Field deployments of …

Human antibodies for viral infections

JE Crowe Jr - Annual review of immunology, 2022 - annualreviews.org
Antibodies have been used to prevent or treat viral infections since the nineteenth century,
but the full potential to use passive immunization for infectious diseases has yet to be …

Mimicking superinfection exclusion disrupts alphavirus infection and transmission in the yellow fever mosquito Aedes aegypti

CM Reitmayer, E Levitt, S Basu… - Proceedings of the …, 2023 - National Acad Sciences
Multiple viruses, including pathogenic viruses, bacteriophages, and even plant viruses,
cause a phenomenon termed superinfection exclusion whereby a currently infected cell is …

Inherently confinable split-drive systems in Drosophila

G Terradas, AB Buchman, JB Bennett, I Shriner… - Nature …, 2021 - nature.com
CRISPR-based gene-drive systems, which copy themselves via gene conversion mediated
by the homology-directed repair (HDR) pathway, have the potential to revolutionize vector …

Manipulating the destiny of wild populations using CRISPR

R Raban, JM Marshall, BA Hay… - Annual review of …, 2023 - annualreviews.org
Genetic biocontrol aims to suppress or modify populations of species to protect public
health, agriculture, and biodiversity. Advancements in genome engineering technologies …

A Review: Wolbachia-Based Population Replacement for Mosquito Control Shares Common Points with Genetically Modified Control Approaches

PS Yen, AB Failloux - Pathogens, 2020 - mdpi.com
The growing expansion of mosquito vectors has made mosquito-borne arboviral diseases a
global threat to public health, and the lack of licensed vaccines and treatments highlight the …

Advances and challenges in synthetic biology for mosquito control

SC Weng, RA Masri, OS Akbari - Trends in parasitology, 2024 - cell.com
Mosquito-borne illnesses represent a significant global health peril, resulting in
approximately one million fatalities annually. West Nile, dengue, Zika, and malaria are …

Dengue virus neutralizing antibody: a review of targets, cross-reactivity, and antibody-dependent enhancement

A Sarker, N Dhama, RD Gupta - Frontiers in immunology, 2023 - frontiersin.org
Dengue is the most common viral infection spread by mosquitoes, prevalent in tropical
countries. The acute dengue virus (DENV) infection is a benign and primarily febrile illness …

Assessment of a split homing based gene drive for efficient knockout of multiple genes

NP Kandul, J Liu, A Buchman, VM Gantz… - G3: Genes …, 2020 - academic.oup.com
Homing based gene drives (HGD) possess the potential to spread linked cargo genes into
natural populations and are poised to revolutionize population control of animals. Given that …