The importance of patient-reported outcomes in clinical trials and strategies for future optimization
R Mercieca-Bebber, MT King, MJ Calvert… - Patient related …, 2018 - Taylor & Francis
Patient-reported outcomes (PROs) can be included in clinical trials as primary or secondary
endpoints and are increasingly recognized by regulators, clinicians, and patients as …
endpoints and are increasingly recognized by regulators, clinicians, and patients as …
International standards for the analysis of quality-of-life and patient-reported outcome endpoints in cancer randomised controlled trials: recommendations of the …
Summary Patient-reported outcomes (PROs), such as symptoms, function, and other health-
related quality-of-life aspects, are increasingly evaluated in cancer randomised controlled …
related quality-of-life aspects, are increasingly evaluated in cancer randomised controlled …
Guidelines for inclusion of patient-reported outcomes in clinical trial protocols: the SPIRIT-PRO extension
Importance Patient-reported outcome (PRO) data from clinical trials can provide valuable
evidence to inform shared decision making, labeling claims, clinical guidelines, and health …
evidence to inform shared decision making, labeling claims, clinical guidelines, and health …
Increasing value and reducing waste in biomedical research: who's listening?
The biomedical research complex has been estimated to consume almost a quarter of a
trillion US dollars every year. Unfortunately, evidence suggests that a high proportion of this …
trillion US dollars every year. Unfortunately, evidence suggests that a high proportion of this …
SPIRIT-PRO Extension explanation and elaboration: guidelines for inclusion of patient-reported outcomes in protocols of clinical trials
Patient-reported outcomes (PROs) are used in clinical trials to provide valuable evidence on
the impact of disease and treatment on patients' symptoms, function and quality of life. High …
the impact of disease and treatment on patients' symptoms, function and quality of life. High …
Analysing data from patient-reported outcome and quality of life endpoints for cancer clinical trials: a start in setting international standards
Measures of health-related quality of life (HRQOL) and other patient-reported outcomes
generate important data in cancer randomised trials to assist in assessing the risks and …
generate important data in cancer randomised trials to assist in assessing the risks and …
Ethical considerations for the inclusion of patient-reported outcomes in clinical research: the PRO ethics guidelines
Importance Patient-reported outcomes (PROs) can inform health care decisions, regulatory
decisions, and health care policy. They also can be used for audit/benchmarking and …
decisions, and health care policy. They also can be used for audit/benchmarking and …
Reminding peer reviewers of reporting guideline items to improve completeness in published articles: primary results of 2 randomized trials
B Speich, E Mann, CM Schönenberger… - JAMA Network …, 2023 - jamanetwork.com
Importance Numerous studies have shown that adherence to reporting guidelines is
suboptimal. Objective To evaluate whether asking peer reviewers to check if specific …
suboptimal. Objective To evaluate whether asking peer reviewers to check if specific …
Design, implementation and reporting strategies to reduce the instance and impact of missing patient-reported outcome (PRO) data: a systematic review
R Mercieca-Bebber, MJ Palmer, M Brundage… - BMJ open, 2016 - bmjopen.bmj.com
Objectives Patient-reported outcomes (PROs) provide important information about the
impact of treatment from the patients' perspective. However, missing PRO data may …
impact of treatment from the patients' perspective. However, missing PRO data may …
Systematic evaluation of patient-reported outcome protocol content and reporting in cancer trials
Abstract Background Patient-reported outcomes (PROs) are captured within cancer trials to
help future patients and their clinicians make more informed treatment decisions. However …
help future patients and their clinicians make more informed treatment decisions. However …