Cannabidiol: State of the art and new challenges for therapeutic applications

S Pisanti, AM Malfitano, E Ciaglia, A Lamberti… - Pharmacology & …, 2017 - Elsevier
Over the past years, several lines of evidence support a therapeutic potential of Cannabis
derivatives and in particular phytocannabinoids. Δ 9-THC and cannabidiol (CBD) are the …

Medically useful plant terpenoids: biosynthesis, occurrence, and mechanism of action

ME Bergman, B Davis, MA Phillips - Molecules, 2019 - mdpi.com
Specialized plant terpenoids have found fortuitous uses in medicine due to their
evolutionary and biochemical selection for biological activity in animals. However, these …

Randomized, dose-ranging safety trial of cannabidiol in Dravet syndrome

O Devinsky, AD Patel, EA Thiele, MH Wong… - Neurology, 2018 - AAN Enterprises
Objective To evaluate the safety and preliminary pharmacokinetics of a pharmaceutical
formulation of purified cannabidiol (CBD) in children with Dravet syndrome. Methods …

[HTML][HTML] Clinicians' guide to cannabidiol and hemp oils

HJ VanDolah, BA Bauer, KF Mauck - Mayo Clinic Proceedings, 2019 - Elsevier
Cannabidiol (CBD) oils are low tetrahydrocannabinol products derived from Cannabis sativa
that have become very popular over the past few years. Patients report relief for a variety of …

Medicinal properties of cannabinoids, terpenes, and flavonoids in cannabis, and benefits in migraine, headache, and pain: an update on current evidence and …

EP Baron - Headache: The Journal of Head and Face Pain, 2018 - Wiley Online Library
Background Comprehensive literature reviews of historical perspectives and evidence
supporting cannabis/cannabinoids in the treatment of pain, including migraine and …

Adenosine, caffeine, and sleep–wake regulation: state of the science and perspectives

CF Reichert, T Deboer, HP Landolt - Journal of sleep research, 2022 - Wiley Online Library
For hundreds of years, mankind has been influencing its sleep and waking state through the
adenosinergic system. For~ 100 years now, systematic research has been performed, first …

Interactions between cannabidiol and commonly used antiepileptic drugs

TE Gaston, EM Bebin, GR Cutter, Y Liu… - …, 2017 - Wiley Online Library
Objective To identify potential pharmacokinetic interactions between the pharmaceutical
formulation of cannabidiol (CBD; Epidiolex) and the commonly used antiepileptic drugs …

[HTML][HTML] Review of the neurological benefits of phytocannabinoids

J Maroon, J Bost - Surgical neurology international, 2018 - ncbi.nlm.nih.gov
Background: Numerous physical, psychological, and emotional benefits have been
attributed to marijuana since its first reported use in 2,600 BC in a Chinese pharmacopoeia …

[HTML][HTML] Cannabinoids in the treatment of epilepsy: hard evidence at last?

E Perucca - Journal of epilepsy research, 2017 - ncbi.nlm.nih.gov
The interest in cannabis-based products for the treatment of refractory epilepsy has
skyrocketed in recent years. Marijuana and other cannabis products with high content in Δ …

[HTML][HTML] The neuropsychopharmacology of cannabis: A review of human imaging studies

MAP Bloomfield, C Hindocha, SF Green… - Pharmacology & …, 2019 - Elsevier
The laws governing cannabis are evolving worldwide and associated with changing
patterns of use. The main psychoactive drug in cannabis is Δ 9-tetrahydrocannabinol (THC) …