Sleep spindles: mechanisms and functions
LMJ Fernandez, A Lüthi - Physiological reviews, 2020 - journals.physiology.org
Sleep spindles are burstlike signals in the electroencephalogram (EEG) of the sleeping
mammalian brain and electrical surface correlates of neuronal oscillations in thalamus. As …
mammalian brain and electrical surface correlates of neuronal oscillations in thalamus. As …
Sodium channelopathies of skeletal muscle and brain
M Mantegazza, S Cestèle… - Physiological …, 2021 - journals.physiology.org
Voltage-gated sodium channels initiate action potentials in nerve, skeletal muscle, and other
electrically excitable cells. Mutations in them cause a wide range of diseases. These …
electrically excitable cells. Mutations in them cause a wide range of diseases. These …
Complement factor C1q mediates sleep spindle loss and epileptic spikes after mild brain injury
INTRODUCTION Traumatic brain injury (TBI) is a leading cause of disability in children and
adults. TBI affects 69 million people worldwide yearly and can lead to cognitive dysfunction …
adults. TBI affects 69 million people worldwide yearly and can lead to cognitive dysfunction …
Generation of ventralized human thalamic organoids with thalamic reticular nucleus
Human brain organoids provide unique platforms for modeling several aspects of human
brain development and pathology. However, current brain organoid systems mostly lack the …
brain development and pathology. However, current brain organoid systems mostly lack the …
Microglial pattern recognition via IL-33 promotes synaptic refinement in developing corticothalamic circuits in mice
Microglia are critical regulators of brain development that engulf synaptic proteins during
postnatal synapse remodeling. However, the mechanisms through which microglia sense …
postnatal synapse remodeling. However, the mechanisms through which microglia sense …
Enhancing GAT-3 in thalamic astrocytes promotes resilience to brain injury in rodents
Inflammatory processes induced by brain injury are important for recovery; however, when
uncontrolled, inflammation can be deleterious, likely explaining why most anti-inflammatory …
uncontrolled, inflammation can be deleterious, likely explaining why most anti-inflammatory …
An epilepsy-associated KCNT1 mutation enhances excitability of human iPSC-derived neurons by increasing slack KNa currents
IH Quraishi, S Stern, KP Mangan, Y Zhang… - Journal of …, 2019 - Soc Neuroscience
Mutations in the KCNT1 (Slack, KNa1. 1) sodium-activated potassium channel produce
severe epileptic encephalopathies. Expression in heterologous systems has shown that the …
severe epileptic encephalopathies. Expression in heterologous systems has shown that the …
SCN1A/NaV1.1 channelopathies: Mechanisms in expression systems, animal models, and human iPSC models
M Mantegazza, V Broccoli - Epilepsia, 2019 - Wiley Online Library
Summary Pathogenic SCN 1A/NaV1. 1 mutations cause well‐defined epilepsies, including
genetic epilepsy with febrile seizures plus (GEFS+) and the severe epileptic encephalopathy …
genetic epilepsy with febrile seizures plus (GEFS+) and the severe epileptic encephalopathy …
[HTML][HTML] Thalamocortical circuits in generalized epilepsy: Pathophysiologic mechanisms and therapeutic targets
Generalized epilepsy affects 24 million people globally; at least 25% of cases remain
medically refractory. The thalamus, with widespread connections throughout the brain, plays …
medically refractory. The thalamus, with widespread connections throughout the brain, plays …
Analysing an allelic series of rare missense variants of CACNA1I in a Swedish schizophrenia cohort
D Baez-Nieto, A Allen, S Akers-Campbell, L Yang… - Brain, 2022 - academic.oup.com
CACNA1I is implicated in the susceptibility to schizophrenia by large-scale genetic
association studies of single nucleotide polymorphisms. However, the channelopathy of …
association studies of single nucleotide polymorphisms. However, the channelopathy of …