ERK signalling: a master regulator of cell behaviour, life and fate

H Lavoie, J Gagnon, M Therrien - Nature reviews Molecular cell biology, 2020 - nature.com
The proteins extracellular signal-regulated kinase 1 (ERK1) and ERK2 are the downstream
components of a phosphorelay pathway that conveys growth and mitogenic signals largely …

ERK: a double-edged sword in cancer. ERK-dependent apoptosis as a potential therapeutic strategy for cancer

R Sugiura, R Satoh, T Takasaki - Cells, 2021 - mdpi.com
The RAF/MEK/ERK signaling pathway regulates diverse cellular processes as exemplified
by cell proliferation, differentiation, motility, and survival. Activation of ERK1/2 generally …

[HTML][HTML] The global phosphorylation landscape of SARS-CoV-2 infection

M Bouhaddou, D Memon, B Meyer, KM White… - Cell, 2020 - cell.com
The causative agent of the coronavirus disease 2019 (COVID-19) pandemic, severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), has infected millions and killed …

The MEK/ERK network as a therapeutic target in human cancer

R Barbosa, LA Acevedo, R Marmorstein - Molecular Cancer Research, 2021 - AACR
Abstract The RAS–RAF–MEK–ERK pathway is the most well-studied of the MAPK cascades
and is critical for cell proliferation, differentiation, and survival. Abnormalities in regulation …

[HTML][HTML] The MAPK cascades: signaling components, nuclear roles and mechanisms of nuclear translocation

A Plotnikov, E Zehorai, S Procaccia, R Seger - Biochimica et Biophysica …, 2011 - Elsevier
The MAPK cascades are central signaling pathways that regulate a wide variety of
stimulated cellular processes, including proliferation, differentiation, apoptosis and stress …

Nuclear ERK: mechanism of translocation, substrates, and role in cancer

G Maik-Rachline, A Hacohen-Lev-Ran… - International journal of …, 2019 - mdpi.com
The extracellular signal-regulated kinases 1/2 (ERK) are central signaling components that
regulate stimulated cellular processes such as proliferation and differentiation. When …

Extracellular signal-regulated kinase: a regulator of cell growth, inflammation, chondrocyte and bone cell receptor-mediated gene expression

N Lu, CJ Malemud - International journal of molecular sciences, 2019 - mdpi.com
Extracellular signal-regulated kinase (ERK) is a member of the mitogen-activated protein
kinase family of signaling molecules. ERK is predominantly found in two forms, ERK1 (p44) …

The ERK cascade: distinct functions within various subcellular organelles

I Wortzel, R Seger - Genes & cancer, 2011 - journals.sagepub.com
The extracellular signal-regulated kinase 1/2 (ERK1/2) cascade is a central signaling
pathway that regulates a wide variety of stimulated cellular processes, including mainly …

How ERK1/2 activation controls cell proliferation and cell death: Is subcellular localization the answer?

Y Mebratu, Y Tesfaigzi - Cell cycle, 2009 - Taylor & Francis
Extracellular signal-regulated protein kinases 1 and 2 (ERK1/2) are members of the mitogen-
activated protein kinase super family that can mediate cell proliferation and apoptosis. The …

Differential regulation and properties of MAPKs

M Raman, W Chen, MH Cobb - Oncogene, 2007 - nature.com
Mitogen-activated protein kinases (MAPKs) regulate diverse cellular programs including
embryogenesis, proliferation, differentiation and apoptosis based on cues derived from the …