Protein phosphorylation on serine and threonine residues is a widely distributed post-
translational modification on proteins that acts to regulate their function. Phosphoprotein …

Chromothripsis, the shattering and imperfect reassembly of one (or a few) chromosome (s),
is an ubiquitous mutational process generating localized and complex chromosomal …

Abstract BRCA1/2-mutated cancer cells adapt to the genome instability caused by their
deficiency in homologous recombination (HR). Identification of these adaptive mechanisms …

Complex genome rearrangements can be generated by the catastrophic pulverization of
missegregated chromosomes trapped within micronuclei through a process known as …

As a deubiquitination (DUB) enzyme, ubiquitin-specific protease 13 (USP13) is involved in a
myriad of cellular processes, such as mitochondrial energy metabolism, autophagy, DNA …

The protein phosphatase 2A (PP2A) heterotrimer PP2A-B56α is a human tumour
suppressor. However, the molecular mechanisms inhibiting PP2A-B56α in cancer are poorly …

We have previously identified TopBP1 (topoisomerase IIβ-binding protein 1) as a promising
target for cancer therapy, given its role in the convergence of Rb, PI (3) K/Akt, and p53 …

The accurate repair of DNA double-strand breaks (DSBs), highly toxic DNA lesions, is
crucial for genome integrity and is tightly regulated during the cell cycle. In mitosis, cells …

Because DNA double-strand breaks (DSBs) greatly threaten genomic integrity, effective
DNA damage sensing and repair are essential for cellular survival in all organisms …

Tumor cells are usually considered defective in mitochondrial respiration, but human non-
small cell lung cancer (NSCLC) tumor tissues are shown to have enhanced glucose …