The molecular mechanisms and signalling pathways that regulate the in vitro preservation of
distinct pluripotent stem cell configurations, and their induction in somatic cells by direct …

Stem cells self-renew and generate specialized progeny through differentiation, but vary in
the range of cells and tissues they generate, a property called developmental potency …

Skin is the largest human organ. Skin continually reconstructs itself to ensure its viability,
integrity, and ability to provide protection for the body. Some areas of skin are continuously …

Human adult spermatogonial stem cells (hSSCs) must balance self-renewal and
differentiation. To understand how this is achieved, we profiled DNA methylation and open …

The generation of induced pluripotent stem cells (iPSCs) from somatic cells demonstrated
that adult mammalian cells can be reprogrammed to a pluripotent state by the enforced …

Pluripotency pertains to the cells of early embryos that can generate all of the tissues in the
organism. Embryonic stem cells are embryo-derived cell lines that retain pluripotency and …

After maternal predetermination gives way to zygotic regulation, a ground state is
established within the mammalian embryo. This tabula rasa for embryogenesis is present …

Reprogramming somatic cells to induced pluripotent stem (iPS) cells has been
accomplished by expressing pluripotency factors and oncogenes,,,,,,,, but the low frequency …

Two major functions of the mammalian ovary are the production of germ cells (oocytes),
which allow continuation of the species, and the generation of bioactive molecules, primarily …

Direct reprogramming of somatic cells to induced pluripotent stem cells by ectopic
expression of defined transcription factors has raised fundamental questions regarding the …