Abstract The Centers for Medicare & Medicaid Services (CMS) introduced the Severe
Sepsis/Septic Shock Management Bundle (SEP-1) as a pay-for-reporting measure in 2015 …

Rationale: Shorter time-to-antibiotics improves survival from sepsis, particularly among
patients in shock. There may be other subgroups for whom faster antibiotics are particularly …

Landmark studies published almost 20 years ago documented strong associations between
time-to-antibiotics and mortality in critically ill patients, most of whom had septic shock.(1-3) …

Objectives: To assess the impact of different methods of calculating Sequential Organ
Failure Assessment (SOFA) scores using electronic health record data on the incidence …

Timely and appropriate antibiotics are the single most effective treatment for patients with
sepsis or septic shock (1, 2). Bedside clinicians charged with treating sepsis, however, face …

Background: Pneumonia is the most common intensive care unit (ICU)-acquired infection
and source of potential sepsis in ICU populations but can be difficult to diagnose in real …

Sepsis, the syndrome of life-threatening organ dysfunction that arises from the host
response to infection, remains a leading cause of morbidity and mortality (1). Timely …

Objective Recent clinical guidelines for sepsis management emphasize immediate antibiotic
initiation for suspected septic shock. Though hypotension is a high‐risk marker of sepsis …

Objectives: Patient safety practices (PSPs) focused on sepsis prediction and recognition,
encompass interventions designed to identify patients with sepsis early and improve timely …

Objective: To evaluate the prevalence, risk factors, and clinical impact of delays in second
doses of antibiotics in patients with sepsis. Design: Single-center, retrospective …