The TAM family: phosphatidylserine-sensing receptor tyrosine kinases gone awry in cancer
The TYRO3, AXL (also known as UFO) and MERTK (TAM) family of receptor tyrosine
kinases (RTKs) are aberrantly expressed in multiple haematological and epithelial …
kinases (RTKs) are aberrantly expressed in multiple haematological and epithelial …
TAM receptor signaling in immune homeostasis
CV Rothlin, EA Carrera-Silva, L Bosurgi… - Annual review of …, 2015 - annualreviews.org
The TAM receptor tyrosine kinases (RTKs)—T YRO3, A XL, and M ERTK—together with their
cognate agonists GAS6 and PROS1 play an essential role in the resolution of inflammation …
cognate agonists GAS6 and PROS1 play an essential role in the resolution of inflammation …
Mer regulates microglial/macrophage M1/M2 polarization and alleviates neuroinflammation following traumatic brain injury
Background Traumatic brain injury (TBI) is a leading cause of death and disability
worldwide. Microglial/macrophage activation and neuroinflammation are key cellular events …
worldwide. Microglial/macrophage activation and neuroinflammation are key cellular events …
Axl mediates ZIKA virus entry in human glial cells and modulates innate immune responses
L Meertens, A Labeau, O Dejarnac, S Cipriani… - Cell reports, 2017 - cell.com
ZIKA virus (ZIKV) is an emerging pathogen responsible for neurological disorders and
congenital microcephaly. However, the molecular basis for ZIKV neurotropism remains …
congenital microcephaly. However, the molecular basis for ZIKV neurotropism remains …
Expression analysis highlights AXL as a candidate Zika virus entry receptor in neural stem cells
TJ Nowakowski, AA Pollen, E Di Lullo… - Cell stem cell, 2016 - cell.com
The recent outbreak of Zika virus (ZIKV) in Brazil has been linked to substantial increases in
fetal abnormalities and microcephaly. However, information about the underlying molecular …
fetal abnormalities and microcephaly. However, information about the underlying molecular …
TAM receptors regulate multiple features of microglial physiology
Microglia are damage sensors for the central nervous system (CNS), and the phagocytes
responsible for routine non-inflammatory clearance of dead brain cells. Here we show that …
responsible for routine non-inflammatory clearance of dead brain cells. Here we show that …
[HTML][HTML] Axl as a mediator of cellular growth and survival
H Axelrod, KJ Pienta - Oncotarget, 2014 - ncbi.nlm.nih.gov
The control of cellular growth and proliferation is key to the maintenance of homeostasis.
Survival, proliferation, and arrest are regulated, in part, by Growth Arrest Specific 6 (Gas6) …
Survival, proliferation, and arrest are regulated, in part, by Growth Arrest Specific 6 (Gas6) …
Protective and pathological immunity during central nervous system infections
The concept of immune privilege of the central nervous system (CNS) has dominated the
study of inflammatory processes in the brain. However, clinically relevant models have …
study of inflammatory processes in the brain. However, clinically relevant models have …
The immune system and psychiatric disease: a basic science perspective
FC Bennett, AV Molofsky - Clinical & Experimental Immunology, 2019 - academic.oup.com
Mental illness exerts a major burden on human health, yet evidence-based treatments are
rudimentary due to a limited understanding of the underlying pathologies. Clinical studies …
rudimentary due to a limited understanding of the underlying pathologies. Clinical studies …
Tissue-specific modifier alleles determine Mertk loss-of-function traits
Knockout (KO) mouse models play critical roles in elucidating biological processes behind
disease-associated or disease-resistant traits. As a presumed consequence of gene KO …
disease-associated or disease-resistant traits. As a presumed consequence of gene KO …