MYC: a multipurpose oncogene with prognostic and therapeutic implications in blood malignancies
MYC oncogene is a transcription factor with a wide array of functions affecting cellular
activities such as cell cycle, apoptosis, DNA damage response, and hematopoiesis. Due to …
activities such as cell cycle, apoptosis, DNA damage response, and hematopoiesis. Due to …
DNA damage response genes and the development of cancer metastasis
CG Broustas, HB Lieberman - Radiation research, 2014 - meridian.allenpress.com
DNA damage response genes play vital roles in the maintenance of a healthy genome.
Defects in cell cycle checkpoint and DNA repair genes, especially mutation or aberrant …
Defects in cell cycle checkpoint and DNA repair genes, especially mutation or aberrant …
Direct regulation of TWIST by HIF-1α promotes metastasis
Stabilization of the hypoxia-inducible factor-1α (HIF-1α) transcription complex, caused by
intratumoural hypoxia, promotes tumour progression and metastasis, leading to treatment …
intratumoural hypoxia, promotes tumour progression and metastasis, leading to treatment …
MYC in oncogenesis and as a target for cancer therapies
A Albihn, JI Johnsen, MA Henriksson - Advances in cancer research, 2010 - Elsevier
Abstract MYC proteins (c-MYC, MYCN, and MYCL) regulate processes involved in many if
not all aspects of cell fate. Therefore, it is not surprising that the MYC genes are deregulated …
not all aspects of cell fate. Therefore, it is not surprising that the MYC genes are deregulated …
L1CAM regulates DNA damage checkpoint response of glioblastoma stem cells through NBS1
L Cheng, Q Wu, Z Huang, OA Guryanova… - The EMBO …, 2011 - embopress.org
Glioblastomas (GBMs) are highly lethal brain tumours with current therapies limited to
palliation due to therapeutic resistance. We previously demonstrated that GBM stem cells …
palliation due to therapeutic resistance. We previously demonstrated that GBM stem cells …
c-MYC-induced genomic instability
A Kuzyk, S Mai - Cold Spring Harbor perspectives …, 2014 - perspectivesinmedicine.cshlp.org
MYC dysregulation initiates a dynamic process of genomic instability that is linked to tumor
initiation. Early studies using MYC-carrying retroviruses showed that these viruses were …
initiation. Early studies using MYC-carrying retroviruses showed that these viruses were …
FOXM1 targets NBS1 to regulate DNA damage-induced senescence and epirubicin resistance
P Khongkow, U Karunarathna, M Khongkow, C Gong… - Oncogene, 2014 - nature.com
FOXM1 is implicated in genotoxic drug resistance but its mechanism of action remains
elusive. We show here that FOXM1-depletion can sensitize breast cancer cells and mouse …
elusive. We show here that FOXM1-depletion can sensitize breast cancer cells and mouse …
Overexpression of NBS1 induces epithelial–mesenchymal transition and co-expression of NBS1 and Snail predicts metastasis of head and neck cancer
Major causes of head and neck squamous cell carcinoma (HNSCC)-related deaths are
cervical node and distant metastasis. We previously demonstrated that overexpression of …
cervical node and distant metastasis. We previously demonstrated that overexpression of …
c-Myc induces chromosomal rearrangements through telomere and chromosome remodeling in the interphase nucleus
SF Louis, BJ Vermolen, Y Garini… - Proceedings of the …, 2005 - National Acad Sciences
In previous work, we showed that telomeres of normal cells are organized within the 3D
space of the interphase nucleus in a nonoverlapping and cell cycle-dependent manner. This …
space of the interphase nucleus in a nonoverlapping and cell cycle-dependent manner. This …
Interaction between HSP60 and β-catenin promotes metastasis
Abstract Heat shock protein 60 (HSP60) plays an essential role in assisting many newly
synthesized proteins to reach their native forms. Increased HSP60 expression is observed in …
synthesized proteins to reach their native forms. Increased HSP60 expression is observed in …