Cancer metastases to bone: concepts, mechanisms, and interactions with bone osteoblasts

AB Shupp, AD Kolb, D Mukhopadhyay, KM Bussard - Cancers, 2018 - mdpi.com
The skeleton is a unique structure capable of providing support for the body. Bone
resorption and deposition are controlled in a tightly regulated balance between osteoblasts …

Bone metastasis and immune checkpoint inhibitors in non-small cell lung cancer (NSCLC): microenvironment and possible clinical implications

A Del Conte, E De Carlo, E Bertoli, B Stanzione… - International journal of …, 2022 - mdpi.com
Patients with non-small cell lung cancer (NSCLC) develop bone metastasis (BoM) in more
than 50% of cases during the course of the disease. This metastatic site can lead to the …

Survival after bone metastasis by primary cancer type: a Danish population-based cohort study

E Svensson, CF Christiansen, SP Ulrichsen… - BMJ open, 2017 - bmjopen.bmj.com
Objective In the 10 most common primary types with bone metastases, we aimed to examine
survival, further stratifying on bone metastases only or with additional synchronous …

Early phase I study of a 99mTc-labeled anti–programmed death ligand-1 (PD-L1) single-domain antibody in SPECT/CT assessment of PD-L1 expression in non–small …

Y Xing, G Chand, C Liu, GJR Cook… - Journal of Nuclear …, 2019 - Soc Nuclear Med
Immunotherapy with checkpoint inhibitor programmed cell death 1 (PD-1)/programmed
death ligand-1 (PD-L1) antibodies demonstrates improvements in treatment of advanced …

[HTML][HTML] The role of biomarkers in the management of bone-homing malignancies

S D'Oronzo, J Brown, R Coleman - Journal of bone oncology, 2017 - Elsevier
Bone represents a common site of metastasis from several solid tumours, including breast,
prostate and lung malignancies. The onset of bone metastases (BM) is associated not only …

[18F]AlF-NOTA-FAPI-04 PET/CT uptake in metastatic lesions on PET/CT imaging might distinguish different pathological types of lung cancer

Y Wei, K Cheng, Z Fu, J Zheng, Z Mu, C Zhao… - European Journal of …, 2022 - Springer
Purpose Heterogeneity is found in the tumor microenvironment among different pathological
types of tumors. Radionuclide-labeled fibroblast-activation-protein inhibitor (FAPI), as an …

Exercise training as part of lung cancer therapy

V Cavalheri, CL Granger - Respirology, 2020 - Wiley Online Library
Exercise training is playing an increasing role in lung cancer care. Lung cancer is
associated with significant burden to the individual and healthcare system. There is now …

Immune checkpoint inhibitors with or without bone-targeted therapy in NSCLC patients with bone metastases and prognostic significance of neutrophil-to-Lymphocyte …

A Bongiovanni, F Foca, J Menis, SL Stucci… - Frontiers in …, 2021 - frontiersin.org
Introduction Bone metastases (BMs) are a negative prognostic factor in patients with non-
small cell lung cancer (NSCLC). Although immune-checkpoint inhibitors (ICIs) have …

The risk factors of bone metastases in patients with lung cancer

Y Zhou, QF Yu, AF Peng, WL Tong, JM Liu, ZL Liu - Scientific reports, 2017 - nature.com
The risk factors of bone metastasis in patients with lung cancer are still unclear. Here, a
retrospective study including a series of consecutive patients who were diagnosed with lung …

Predictive and prognostic biomarkers for lung cancer bone metastasis and their therapeutic value

X Chai, E Yinwang, Z Wang, Z Wang, Y Xue, B Li… - Frontiers in …, 2021 - frontiersin.org
Lung cancer is the leading cause of cancer-related death worldwide. Bone metastasis,
which usually accompanies severe skeletal-related events, is the most common site for …