Blood vessel endothelial cells (ECs) have long been known to modulate inflammation by
regulating immune cell trafficking, activation status and function. However, whether the …

Background Lipopolysaccharide, a highly potent endotoxin responsible for severe sepsis, is
the major constituent of the outer membrane of gram-negative bacteria. Endothelial cells …

Numerous reports of vascular events after an initial recovery from COVID-19 form our
impetus to investigate the impact of COVID-19 on vascular health of recovered patients. We …

The lungs are constantly exposed to environmental and infectious agents such as dust,
viruses, fungi, and bacteria that invade the lungs upon breathing. The lungs are equipped …

Abstract Coronavirus Disease 2019 (COVID-19) was first identified in China at the end of
2019. Acute respiratory distress syndrome (ARDS) represents the most common and serious …

Allogeneic lung transplantation (LuTx) is considered the treatment of choice for a broad
range of advanced, progressive lung diseases resistant to conventional treatment regimens …

Pediatric patients with constitutively active mutations in the cytosolic double-stranded-DNA-
sensing adaptor STING develop an autoinflammatory syndrome known as STING …

SARS-CoV-2-associated acute respiratory distress syndrome (ARDS) and acute lung injury
are life-threatening manifestations of severe viral infection. The pathogenic mechanisms that …

Acute lung injury/acute respiratory distress syndrome (ALI/ARDS) is a disastrous condition,
which can be caused by a wide range of diseases, such as pneumonia, sepsis, traumas …

Systemic inflammatory processes, including alveolar injury, cytokine induction, and
neutrophil accumulation, play key roles in the pathophysiology of acute lung injury (ALI). The …