A China-developed adenovirus vector-based COVID-19 vaccine: review of the development and application of Ad5-nCov

SY Wang, WQ Liu, YQ Li, JX Li… - Expert Review of Vaccines, 2023 - Taylor & Francis
Introduction The global spread of COVID-19 has prompted the development of vaccines. A
recombinant adenovirus type-5 vectored COVID-19 vaccine (Ad5-nCoV) developed by …

Influenza B: prospects for the development of cross-protective vaccines

LM Tsybalova, LA Stepanova, ES Ramsay, AV Vasin - Viruses, 2022 - mdpi.com
In this review, we analyze the epidemiological and ecological features of influenza B, one of
the most common and severe respiratory infections. The review presents various strategies …

Adenoviral-vectored universal influenza vaccines administered intranasally reduce lung inflammatory responses upon viral challenge 15 months post-vaccination

JA Misplon, CY Lo, TA Crabbs, GE Price… - Journal of …, 2023 - Am Soc Microbiol
New approaches to vaccination are needed for protection against rapidly evolving viruses
because emerging variant strains often evade neutralizing antibodies. Alternative strategies …

The protective effect of intranasal immunization with influenza virus recombinant adenovirus vaccine on mucosal and systemic immune response

YB Lian, MJ Hu, TK Guo, YL Yang, RR Zhang… - International …, 2024 - Elsevier
Influenza virus is a kind of virus that poses several hazards of animal and human health.
Therefore, it is important to develop an effective vaccine to prevent influenza. To this end we …

Self-assembled multiepitope nanovaccine based on NoV P particles induces effective and lasting protection against H3N2 influenza virus

J Nie, Q Wang, S Jin, X Yao, L Xu, Y Chang, F Ding… - Nano research, 2023 - Springer
Current seasonal influenza vaccines confer only limited coverage of virus strains due to the
frequent genetic and antigenic variability of influenza virus (IV). Epitope vaccines that …

Synthetic vaccine affords full protection to mice against lethal challenge of influenza B virus of both genetic lineages

C Gravel, A Muralidharan, A Duran, A Zetner, A Pfeifle… - Iscience, 2021 - cell.com
A quarter of all seasonal influenza cases are caused by type B influenza virus (IBV) that also
dominates periodically. Here, we investigated a recombinant adenovirus vaccine carrying a …

H5Nx 禽流感病毒交叉反应性CD4+ T 细胞表位预测

谢爽, 陈瑶, 黄俊琼 - 生物技术通报, 2024 - biotech.aiijournal.com
[目的] 评估预先存在的H5Nx 交叉反应性免疫记忆, 为人类H5 禽流感病毒的防治和广谱疫苗的
研发提供理论数据.[方法] 利用生物信息学方法筛选人源H5Nx 禽流感病毒与季节性流感病毒的 …

Flagellin-Fused Protein Targeting M2e and HA2 Induces Innate and T-Cell Responses in Mice of Different Genetic Lines

LA Stepanova, MA Shuklina, KA Vasiliev, AA Kovaleva… - Vaccines, 2022 - mdpi.com
Efficient control of influenza A infection can potentially be achieved through the development
of broad-spectrum vaccines. Recombinant proteins incorporating conserved influenza A …

Prediction of H5Nx Avian Influenza Virus Cross-reactivity CD4+ T-cell Epitopes

S XIE, Y CHEN, J HUANG - Biotechnology Bulletin, 2024 - biotech.aiijournal.com
[Objective] To evaluate preexisting H5Nx cross-reactivity immune memory and to provide
theoretical data for the prevention and treatment of human H5 avian influenza viruses and …

[PDF][PDF] Conventional and Advanced Approaches in Veterinary Vaccines

N Amin, M Munawar, A Ijaz, A Shaffaq, R Ullah, M Anas… - uniquescientificpublishers.com
Veterinary vaccination is one of the main effective measures to reduce and eradicate
impairment prompted by infectious diseases in animals and humans. Various vaccines are …