Cell signaling in response to an array of diverse stress stimuli converges on the
phosphorylation of the α-subunit of eukaryotic initiation factor 2 (eIF2). Phosphorylation of …

▪ Abstract The Class 2 α-helical cytokines consist of interleukin-10 (IL-10), IL-19, IL-20, IL-22,
IL-24 (Mda-7), and IL-26, interferons (IFN-α,-β,-ε,-κ,-ω,-δ,-τ, and-γ) and interferon-like …

The double-stranded RNA-dependent protein kinase PKR is a critical mediator of the
antiproliferative and antiviral effects exerted by interferons. Not only is PKR an effector …

The IFN-induced double-stranded RNA-dependent protein kinase (PKR) is one of the four
mammalian serine-threonine kinases (the three others being HRI, GCN2 and PERK) that …

Proteasome dysfunction can lead to autoinflammatory disease associated with elevated type
I interferon (IFN-αβ) and NF-κB signaling; however, the innate immune pathway driving this …

Abstract Background Circular RNAs (circRNAs) represent a novel type of regulatory RNA
characterized by high evolutionary conservation and stability. CircRNAs are expected to be …

Class II cytokine receptors were originally defined on the basis of sequence homologies in
the extracellular domains of receptors for interferons (IFNs) and interleukin-10 (IL-10), and …

Cytokines that signal through Class II receptors form a distinct family that includes the
interferons and interleukin 10 (IL-10). Recent identification of several IL-10 homologs has …

The protein kinase R (PKR) is an intracellular sensor of stress, exemplified by viral infection.
Double-stranded (ds) RNA produced during viral replication activates PKR, which in turn …

Translation initiation is regulated in response to nutrient availability and mitogenic
stimulation and is coupled with cell cycle progression and cell growth. Several alterations in …