Multidrug efflux pumps function at the frontline to protect bacteria against antimicrobials by
decreasing the intracellular concentration of drugs. This protective barrier consists of a …

Abstract The Transporter Classification Database (TCDB; http://www. tcdb. org) is a freely
accessible reference database for transport protein research, which provides structural …

Abstract The Transporter Classification Database (TCDB; tcdb. org) is a freely accessible
reference resource, which provides functional, structural, mechanistic, medical and …

The global incidence of drug-resistant Gram-negative bacillary infections has been
increasing, and there is a dire need to develop novel strategies to overcome this problem …

Niemann-Pick disease type C (NPC) is associated with mutations in NPC1 and NPC2,
whose gene products are key players in the endosomal/lysosomal egress of low-density …

Infectious diseases remain one of the principal causes of morbidity and mortality in the
world. Relevant authorities including the WHO and CDC have expressed serious concern …

Lysosomal cholesterol egress requires two proteins, NPC1 and NPC2, whose defects are
responsible for Niemann-Pick disease type C (NPC). Here, we present systematic structural …

Drug efflux protein complexes confer multidrug resistance on bacteria by transporting a wide
spectrum of structurally diverse antibiotics. Moreover, organisms can only acquire resistance …

Objectives To gain a more detailed understanding of endogenous (mutational) and
exogenous (horizontally acquired) resistance to silver in Gram-negative pathogens, with an …

The global public health threat of antimicrobial resistance has led the scientific community to
highly engage into research on alternative strategies to the traditional small molecule …