Structural biology of SARS-CoV-2: open the door for novel therapies

W Yan, Y Zheng, X Zeng, B He, W Cheng - Signal Transduction and …, 2022 - nature.com
Abstract Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) is the causative
agent of the pandemic disease COVID-19, which is so far without efficacious treatment. The …

Structural features of tight-junction proteins

U Heinemann, A Schuetz - International journal of molecular sciences, 2019 - mdpi.com
Tight junctions are complex supramolecular entities composed of integral membrane
proteins, membrane-associated and soluble cytoplasmic proteins engaging in an intricate …

Phase transition in postsynaptic densities underlies formation of synaptic complexes and synaptic plasticity

M Zeng, Y Shang, Y Araki, T Guo, RL Huganir… - Cell, 2016 - cell.com
Postsynaptic densities (PSDs) are membrane semi-enclosed, submicron protein-enriched
cellular compartments beneath postsynaptic membranes, which constantly exchange their …

Structural basis for SARS-CoV-2 envelope protein recognition of human cell junction protein PALS1

J Chai, Y Cai, C Pang, L Wang, S McSweeney… - Nature …, 2021 - nature.com
The COVID-19 pandemic, caused by the SARS-CoV-2 virus, has created global health and
economic emergencies. SARS-CoV-2 viruses promote their own spread and virulence by …

[HTML][HTML] SARS-CoV-2 E protein: Pathogenesis and potential therapeutic development

S Zhou, P Lv, M Li, Z Chen, H Xin, S Reilly… - Biomedicine & …, 2023 - Elsevier
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a devastating
global pandemic, which has seriously affected human health worldwide. The discovery of …

Membrane prewetting by condensates promotes tight-junction belt formation

K Pombo-García, O Adame-Arana, C Martin-Lemaitre… - Nature, 2024 - nature.com
Biomolecular condensates enable cell compartmentalization by acting as membraneless
organelles. How cells control the interactions of condensates with other cellular structures …

Mechanistic basis of MAGUK-organized complexes in synaptic development and signalling

J Zhu, Y Shang, M Zhang - Nature Reviews Neuroscience, 2016 - nature.com
Membrane-associated guanylate kinases (MAGUKs) are a family of scaffold proteins that are
highly enriched in synapses and are responsible for organizing the numerous protein …

Structural basis of coronavirus E protein interactions with human PALS1 PDZ domain

A Javorsky, PO Humbert, M Kvansakul - Communications biology, 2021 - nature.com
SARS-CoV-2 infection leads to coronavirus disease 2019 (COVID-19), which is associated
with severe and life-threatening pneumonia and respiratory failure. However, the molecular …

[HTML][HTML] Supramolecular organization of NMDA receptors and the postsynaptic density

RAW Frank, SGN Grant - Current opinion in neurobiology, 2017 - Elsevier
Highlights•Complexes, supercomplexes and nanodomains are building blocks of the
synapse.•A tripartite mechanism dictates NMDA receptor complex assembly into …

PDZ domains as drug targets

NR Christensen, J Čalyševa… - Advanced …, 2019 - Wiley Online Library
Protein–protein interactions within protein networks shape the human interactome, which
often is promoted by specialized protein interaction modules, such as the postsynaptic …