Anhedonia—the loss of pleasure or lack of reactivity to pleasurable stimuli—remains a
formidable treatment challenge across neuropsychiatric disorders. In major depressive …

Major depressive disorder is a leading cause of disability worldwide. Because conventional
therapies are ineffective in many patients, novel strategies are needed to overcome …

Opioid receptors are widely distributed throughout the brain and play an essential role in
modulating aspects of human mood, reward, and well-being. Accumulating evidence …

Depression has become one of the most prevalent neuropsychiatric disorders characterized
by anhedonia, anxiety, pessimism, or even suicidal thoughts. Receptor theory has been …

Anhedonia remains a major clinical issue for which there is few effective interventions.
Untreated or poorly controlled anhedonia has been linked to worse disease course and …

Amygdaloid circuits are involved in a variety of emotional and motivation-related behaviors
and are impacted by stress. The amygdala expresses several neuromodulatory systems …

The opioid receptors (OR) regulate food intake. Still, despite extensive pre-clinical research,
the overall effects and individual contribution of the mu (MOR), kappa (KOR), and delta …

Rationale Major depressive disorder is a leading cause of disability worldwide and is likely
precipitated by chronic stress. Although many antidepressants are currently available, these …

Background Depressive disorders are common. Many patients with major depression do not
achieve remission with available treatments. Buprenorphine has been raised as a potential …

Migraine is a leading cause of disability worldwide. Despite the recent approval of several
calcitonin gene-related peptide-targeted therapies, many people with migraine do not …