Plant specialized metabolism: diversity of terpene synthases and their products

ME Bergman, N Dudareva - Current Opinion in Plant Biology, 2024 - Elsevier
Terpenoids are ubiquitous to all kingdoms of life and are one of the most diverse groups of
compounds, both structurally and functionally. Despite being derived from common …

Terpene synthases and pathways in animals: enzymology and structural evolution in the biosynthesis of volatile infochemicals

D Tholl, Z Rebholz, AV Morozov… - Natural Product Reports, 2023 - pubs.rsc.org
Covering: up to the beginning of 2023 Many animals release volatile or semi-volatile
terpenes as semiochemicals in intra-and inter-specific interactions. Terpenes are important …

Function and structure of a terpene synthase encoded in a giant virus genome

Y Jung, T Mitsuhashi, S Sato, M Senda… - Journal of the …, 2023 - ACS Publications
Giant viruses are nonstandard viruses with large particles and genomes. While previous
studies have shown that their genomes contain various sequences of interest, their genes …

Triterpene and steroid glycosides from marine sponges (Porifera, Demospongiae): Structures, taxonomical distribution, biological activities

NV Ivanchina, VI Kalinin - Molecules, 2023 - mdpi.com
The article is a comprehensive review concerning tetracyclic triterpene and steroid
glycosides from sponges (Porifera, Demospongiae). The extensive oxidative transformations …

Biosynthesis of Haloterpenoids in Red Algae via Microbial-like Type I Terpene Synthases

TS Steele, I Burkhardt, ML Moore, T de Rond… - ACS chemical …, 2023 - ACS Publications
Red algae or seaweeds produce highly distinctive halogenated terpenoid compounds,
including the pentabromochlorinated monoterpene halomon that was once heralded as a …

[HTML][HTML] Suppression of alpha-tubulin acetylation potentiates therapeutic efficacy of Eribulin in liver cancer

Y Zhong, C Wang, Y Wang, Y Wu, H Wang… - American Journal of …, 2023 - ncbi.nlm.nih.gov
Hepatocellular carcinoma (HCC) is a prevalent cancer with limited effective treatments.
Eribulin mesylate is a novel chemotherapy drug that inhibits microtubule elongation and …

Short macrocyclic peptides in sponge genomes

Z Lin, V Agarwal, Y Cong… - Proceedings of the …, 2024 - National Acad Sciences
Sponges (Porifera) contain many peptide-specialized metabolites with potent biological
activities and significant roles in shaping marine ecology. It is well established that symbiotic …

Discovery and Biosynthesis of Ureidopeptide Natural Products Macrocyclized via Indole N‐acylation in Marine Microbulbifer spp. Bacteria

W Zhong, JM Deutsch, D Yi, NH Abrahamse… - …, 2023 - Wiley Online Library
Commensal bacteria associated with marine invertebrates are underappreciated sources of
chemically novel natural products. Using mass spectrometry, we had previously detected the …

Co-occurring nitrifying symbiont lineages are vertically inherited and widespread in marine sponges

B Glasl, HM Luter, K Damjanovic, K Kitzinger… - The ISME …, 2024 - academic.oup.com
Ammonia-oxidising archaea and nitrite-oxidising bacteria are common members of marine
sponge microbiomes. They derive energy for carbon fixation and growth from nitrification-the …

Innovative approaches in the discovery of terpenoid natural products

S Cheng, X Wang, Z Deng, T Liu - Current Opinion in Microbiology, 2025 - Elsevier
Highlights•High-yield microbial chassis streamline terpene (skeleton) mining.•Automated
high-throughput workstation expedites terpenoid library construction.•Artificial intelligence …