The positive role and mechanism of herbal medicine in Parkinson's disease

R Yin, J Xue, Y Tan, C Fang, C Hu… - Oxidative medicine …, 2021 - Wiley Online Library
Parkinson's disease (PD) is a complex neurodegenerative disease, manifested by the
progressive functional impairment of the midbrain nigral dopaminergic neurons. Due to the …

[HTML][HTML] Astroglial and microglial contributions to iron metabolism disturbance in Parkinson's disease

N Song, J Wang, H Jiang, J Xie - … et Biophysica Acta (BBA)-Molecular Basis …, 2018 - Elsevier
Understandings of the disturbed iron metabolism in Parkinson's disease (PD) are largely
from the perspectives of neurons. Neurodegenerative processes in PD trigger universal and …

Apoferritin improves motor deficits in MPTP-treated mice by regulating brain iron metabolism and ferroptosis

LM Song, ZX Xiao, N Zhang, XQ Yu, W Cui, JX Xie… - IScience, 2021 - cell.com
Iron deposition is one of the key factors in the etiology of Parkinson's disease (PD). Iron-free-
apoferritin has the ability to store iron by combining with a ferric hydroxide-phosphate …

Vitamin D and the risks of depression and anxiety: an observational analysis and genome-wide environment interaction study

Z Zhang, X Yang, Y Jia, Y Wen, S Cheng, P Meng, C Li… - Nutrients, 2021 - mdpi.com
Previous studies have suggested that vitamin D (VD) was associated with psychiatric
diseases, but efforts to elucidate the functional relevance of VD with depression and anxiety …

JWH133 inhibits MPP+-induced inflammatory response and iron influx in astrocytes

Y Jia, H Deng, Q Qin, ZG Ma - Neuroscience letters, 2020 - Elsevier
Background We investigated the anti-inflammatory effect of type II cannabinoid receptor (CB
2 receptor) activation and their relationship to iron influx on 1-methyl-4-phenylpyridinium …

New insights into the crosstalk between NMDARs and iron: Implications for understanding pathology of neurological diseases

H Xu, H Jiang, J Xie - Frontiers in Molecular Neuroscience, 2017 - frontiersin.org
Both iron dyshomeostasis and N-methyl-D-aspartate receptors (NMDARs)-mediated
neurotoxicity have been shown to have an important role in neurological diseases such as …

Relevant Membrane Transport Proteins as Possible Gatekeepers for Effective Pharmacological Ascorbate Treatment in Cancer

C Leischner, L Marongiu, A Piotrowsky, H Niessner… - Antioxidants, 2023 - mdpi.com
Despite the increasing number of newly diagnosed malignancies worldwide, therapeutic
options for some tumor diseases are unfortunately still limited. Interestingly, preclinical but …

Metalloproteins and metalloproteomics in health and disease

IH Ibrahim - Advances in Protein Chemistry and Structural Biology, 2024 - Elsevier
Metalloproteins represents more than one third of human proteome, with huge variation in
physiological functions and pathological implications, depending on the metal/metals …

The genetic variants of solute carrier family 11 member 2 gene and risk of developing type-2 diabetes

C Ozbayer, H Kurt, MN Kebapci, HV Gunes, E Colak… - Journal of genetics, 2018 - Springer
Abstract Type-2 diabetes (T2DM) is a metabolic disorder characterized by long-term insulin
resistance, impaired insulin secretion from\upbeta β-cells, and loss of beta cell mass and …

Iron metabolism in autism spectrum disorder; inference through single nucleotide polymorphisms in key iron metabolism genes

S Rabaya, S Nairat, K Bader, MM Herzallah… - Journal of the …, 2023 - Elsevier
Autism spectrum disorder (ASD) is a heterogeneous group of neurodevelopmental problems
with various genetic and environmental components. The ASD diagnosis is based on …