[HTML][HTML] Circuit mechanisms of Parkinson's disease
MM McGregor, AB Nelson - Neuron, 2019 - cell.com
Parkinson's disease (PD) is a complex, multi-system neurodegenerative disorder. The
second most common neurodegenerative disorder after Alzheimer's disease, it affects …
second most common neurodegenerative disorder after Alzheimer's disease, it affects …
Emerging technologies for improved deep brain stimulation
Deep brain stimulation (DBS) is an effective treatment for common movement disorders and
has been used to modulate neural activity through delivery of electrical stimulation to key …
has been used to modulate neural activity through delivery of electrical stimulation to key …
Pathophysiology of L-dopa-induced motor and non-motor complications in Parkinson's disease
Involuntary movements, or dyskinesia, represent a debilitating complication of levodopa (L-
dopa) therapy for Parkinson's disease (PD). L-dopa-induced dyskinesia (LID) are ultimately …
dopa) therapy for Parkinson's disease (PD). L-dopa-induced dyskinesia (LID) are ultimately …
Cerebellar contributions to the basal ganglia influence motor coordination, reward processing, and movement vigor
Both the cerebellum and the basal ganglia are known for their roles in motor control and
motivated behavior. These two systems have been classically considered as independent …
motivated behavior. These two systems have been classically considered as independent …
Mechanism of deep brain stimulation: inhibition, excitation, or disruption?
S Chiken, A Nambu - The neuroscientist, 2016 - journals.sagepub.com
Deep brain stimulation (DBS), applying high-frequency electrical stimulation to deep brain
structures, has now provided an effective therapeutic option for treatment of various …
structures, has now provided an effective therapeutic option for treatment of various …
Cellular, molecular, and clinical mechanisms of action of deep brain stimulation—a systematic review on established indications and outlook on future developments
Deep brain stimulation (DBS) has been successfully used to treat movement disorders, such
as Parkinson's disease, for more than 25 years and heralded the advent of electrical …
as Parkinson's disease, for more than 25 years and heralded the advent of electrical …
Neurophysiological mechanisms of deep brain stimulation across spatiotemporal resolutions
WJ Neumann, LA Steiner, L Milosevic - Brain, 2023 - academic.oup.com
Deep brain stimulation is a neuromodulatory treatment for managing the symptoms of
Parkinson's disease and other neurological and psychiatric disorders. Electrodes are …
Parkinson's disease and other neurological and psychiatric disorders. Electrodes are …
History, applications, and mechanisms of deep brain stimulation
S Miocinovic, S Somayajula, S Chitnis… - JAMA neurology, 2013 - jamanetwork.com
Deep brain stimulation (DBS) is an effective surgical treatment for medication-refractory
hypokinetic and hyperkinetic movement disorders, and it is being explored for a variety of …
hypokinetic and hyperkinetic movement disorders, and it is being explored for a variety of …
Deep brain stimulation of the subthalamic nucleus for the treatment of Parkinson's disease
High-frequency deep brain stimulation (DBS) of the subthalamic nucleus (STN-HFS) is the
preferred surgical treatment for advanced Parkinson's disease. In the 15 years since its …
preferred surgical treatment for advanced Parkinson's disease. In the 15 years since its …
Pathological synchronization in Parkinson's disease: networks, models and treatments
Parkinson's disease is a common and disabling disorder of movement owing to
dopaminergic denervation of the striatum. However, it is still unclear how this denervation …
dopaminergic denervation of the striatum. However, it is still unclear how this denervation …