The nuclear receptor PPARγ is a ligand-activated transcription factor that plays an important
role in the control of gene expression linked to a variety of physiological processes. PPARγ …

Peroxisome proliferator-activated receptors (PPARs) belong to a family of ligand-activated
nuclear receptors that includes the estrogen, thyroid hormone, and glucocorticoid receptors …

Nonalcoholic fatty liver disease (NAFLD) and its advanced stage, nonalcoholic
steatohepatitis (NASH), are the most common causes of chronic liver disease in the United …

The pro-longevity enzyme SIRT6 regulates various metabolic pathways. Gene expression
analyses in SIRT6 heterozygotic mice identify significant decreases in PPARα signaling …

Intrahepatic fat deposition has been demonstrated in patients with nonalcoholic fatty liver
disease (NAFLD). Genetic and environmental factors are important for the development of …

Human stem cells are powerful tools by which to investigate molecular mechanisms of cell
growth and differentiation under normal and pathological conditions. Hedgehog signaling …

Insulin resistance is a major factor in obesity-linked type 2 diabetes. PPARγ is a master
regulator of adipogenesis, and small molecule agonists, termed thiazolidinediones, are …

ABSTRACT A newly recognized primary cause of obesity epidemic is the developmental
programming effects of (1) intrauterine growth-restricted (IUGR) newborns exposed in utero …

Omega‐3 (or n‐3) polyunsaturated fatty acids (PUFAs) and their metabolites are natural
ligands for peroxisome proliferator receptor activator (PPAR) γ and, due to the effects of …

Sirt1 (member of the sirtuin family) is a nicotinamide adenosine dinucleotide (NAD)-
dependent deacetylase that removes acetyl groups from various proteins. A wide variety of …