During the last two decades, DNA-based molecular markers have been extensively utilized
for a variety of studies in both plant and animal systems. One of the major uses of these …

Assessing the association between DNA variants and disease has been used widely to
identify regions of the genome and candidate genes that contribute to disease. However …

The Bradley-Terry model for paired comparisons is a simple and much-studied means to
describe the probabilities of the possible outcomes when individuals are judged against one …

Muscle cells respond to mechanical stretch stimuli by triggering downstream signals for
myocyte growth and survival. The molecular components of the muscle stretch sensor are …

This paper provides a review of the design and analysis of genetic association studies. In
case control studies, the different contingency tables and their relationships to the …

Bayesian statistics allow scientists to easily incorporate prior knowledge into their data
analysis. Nonetheless, the sheer amount of computational power that is required for …

The pathologies of many infectious, autoimmune and malignant diseases are influenced by
the profiles of cytokine production in pro-inflammatory (TH1) and anti-inflammatory (TH2) T …

Association tests of multilocus haplotypes are of interest both in linkage disequilibrium
mapping and in candidate gene studies. For case‐parent trios, I discuss the extension of …

Compared to the conventional linkage mapping, linkage disequilibrium (LD)‐mapping,
using the nonrandom associations of loci in haplotypes, is a powerful high‐resolution …

The transmission/disequilibrium test (TDT) was introduced several years ago by Spielman et
al.(1993) as a test for linkage between a complex disease and a genetic marker. The …