Wnt, a secreted glycoprotein, has an approximate molecular weight of 40 kDa, and it is a
cytokine involved in various biological phenomena including ontogeny, morphogenesis …

Developmental signaling pathways control a vast array of biological processes during
embryogenesis and in adult life. The WNT pathway was discovered simultaneously in …

Since the initial discovery of the oncogenic activity of WNT1 in mouse mammary glands, our
appreciation for the complex roles for WNT signalling pathways in cancer has increased …

Signaling through the Ror2 receptor tyrosine kinase promotes invadopodia formation for
tumor invasion. Here, we identify intraflagellar transport 20 (IFT20) as a new target of this …

The WNT pathway is one of the major signaling cascades frequently deregulated in human
cancer. While research had initially focused on signal transduction centered on β-catenin as …

Wnt ligands play a central role in the development and homeostasis of various organs
through β-catenin-dependent and-independent signalling. The crucial roles of Wnt/β-catenin …

Wnt5a is a representative ligand that activates the β‐catenin‐independent pathways.
Because the β‐catenin‐independent pathway includes multiple signalling cascades in …

Osteosarcoma is a relatively uncommon cancer, accounting for 5% of childhood cancers
and 8.9% of cancer-related deaths in children. The overall incidence is five cases per million …

Cancer-associated fibroblasts (CAFs) are a crucial component in the tumor
microenvironment influencing cancer progression. Besides shaping the extracellular matrix …

Receptor tyrosine kinases of the Ryk and Ror families were initially classified as orphan
receptors because their ligands were unknown. They are now known to contain functional …