The landscape of the mesenchymal signature in brain tumours

J Behnan, G Finocchiaro, G Hanna - Brain, 2019 - academic.oup.com
The complexity of glioblastoma multiforme, the most common and lethal variant of gliomas,
is reflected by cellular and molecular heterogeneity at both the inter-and intra-tumoural …

[HTML][HTML] Studying human neurological disorders using induced pluripotent stem cells: from 2D monolayer to 3D organoid and blood brain barrier models

S Logan, T Arzua, SG Canfield… - Comprehensive …, 2019 - ncbi.nlm.nih.gov
Neurological disorders have emerged as a predominant healthcare concern in recent years
due to their severe consequences on quality of life and prevalence throughout the world …

Blood–brain barrier disruption and its involvement in neurodevelopmental and neurodegenerative disorders

A Aragón-González, PJ Shaw, L Ferraiuolo - International journal of …, 2022 - mdpi.com
The blood–brain barrier (BBB) is a highly specialized and dynamic compartment which
regulates the uptake of molecules and solutes from the blood. The relevance of the …

Bilirubin-induced neurological damage: current and emerging iPSC-derived brain organoid models

AI Pranty, S Shumka, J Adjaye - Cells, 2022 - mdpi.com
Bilirubin-induced neurological damage (BIND) has been a subject of studies for decades,
yet the molecular mechanisms at the core of this damage remain largely unknown …

Mesenchymal transformation: the rosetta stone of glioblastoma pathogenesis and therapy resistance

Z Azam, SST TO, BA Tannous - Advanced science, 2020 - Wiley Online Library
Despite decades of research, glioblastoma (GBM) remains invariably fatal among all forms
of cancers. The high level of inter‐and intratumoral heterogeneity along with its biological …

The great escape: the power of cancer stem cells to evade programmed cell death

V Castelli, A Giordano, E Benedetti, F Giansanti… - Cancers, 2021 - mdpi.com
Simple Summary Several current therapies fail to eradicate tumors due to the ability of
cancer stem cells (CSCs) to escape different programmed cell deaths. In fact, apoptosis …

[HTML][HTML] Therapeutic effect of a hydrogel-based neural stem cell delivery sheet for mild traumatic brain injury

JT Kim, SM Cho, DH Youn, EP Hong, CH Park, Y Lee… - Acta biomaterialia, 2023 - Elsevier
Objective: There are no effective clinically applicable treatments for neuronal dysfunction
after mild traumatic brain injury (TBI). Here, we evaluated the therapeutic effect of a new …

Differentiation of human mesenchymal stem cells from Wharton's Jelly towards neural stem cells using a feasible and repeatable protocol

E Kruminis-Kaszkiel, A Osowski, E Bejer-Oleńska… - Cells, 2020 - mdpi.com
The transplantation of neural stem cells (NSCs) capable of regenerating to the cells of the
central nervous system (CNS) is a promising strategy in the treatment of CNS diseases and …

Human neural stem cells for cell-based medicinal products

B Fernandez-Muñoz, AB Garcia-Delgado… - Cells, 2021 - mdpi.com
Neural stem cells represent an attractive tool for the development of regenerative therapies
and are being tested in clinical trials for several neurological disorders. Human neural stem …

Modern advances in spinal cord regeneration: hydrogel combined with neural stem cells

O Rybachuk, Y Nesterenko, V Zhovannyk - Frontiers in Pharmacology, 2024 - frontiersin.org
Severe spinal cord injuries (SCI) lead to loss of functional activity of the body below the
injury site, affect a person's ability to self-care and have a direct impact on performance. Due …