Signaling pathways and potential therapeutic targets in acute respiratory distress syndrome (ARDS)

Q Huang, Y Le, S Li, Y Bian - Respiratory Research, 2024 - Springer
Acute respiratory distress syndrome (ARDS) is a common condition associated with critically
ill patients, characterized by bilateral chest radiographical opacities with refractory …

ROS signaling in the pathogenesis of acute lung injury (ALI) and acute respiratory distress syndrome (ARDS)

M Kellner, S Noonepalle, Q Lu, A Srivastava… - … redox signaling in …, 2017 - Springer
The generation of reactive oxygen species (ROS) plays an important role for the
maintenance of cellular processes and functions in the body. However, the excessive …

[HTML][HTML] Effects of glycyrrhizin on lipopolysaccharide-induced acute lung injury in a mouse model

S Am Lee, SH Lee, JY Kim, WS Lee - Journal of Thoracic Disease, 2019 - ncbi.nlm.nih.gov
Background Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are
serious clinical disease entities characterized by inflammatory pulmonary edema, which …

Acetovanillone prevents cyclophosphamide‐induced acute lung injury by modulating PI3K/Akt/mTOR and Nrf2 signaling in rats

OAM Abd El‐Ghafar, EHM Hassanein… - Phytotherapy …, 2021 - Wiley Online Library
Cyclophosphamide (CP) is a medication used as an anticancer drug and to suppress the
immune system. However, its clinical applications are restricted because of the toxic and …

Protective effect of apocynin against gentamicin-induced nephrotoxicity in rats

RS Abdelrahman - Human & experimental toxicology, 2018 - journals.sagepub.com
Gentamicin (GNT) is an aminoglycoside antibiotic used for treatment of serious infections,
and the nephrotoxic adverse effect is one of the main therapeutic limitations. This study …

Myricitrin Modulates NADPH Oxidase‐Dependent ROS Production to Inhibit Endotoxin‐Mediated Inflammation by Blocking the JAK/STAT1 and NOX2/p47phox …

S Qi, Z Feng, Q Li, Z Qi, Y Zhang - Oxidative Medicine and …, 2017 - Wiley Online Library
Myricitrin, a naturally occurring polyphenol hydroxy flavonoid, has been reported to possess
anti‐inflammatory properties. However, the precise molecular mechanism of myricitrin's …

Vincamine, an active constituent of Vinca rosea ameliorates experimentally induced acute lung injury in Swiss albino mice through modulation of Nrf-2/NF-κB …

AP Renushe, AK Banothu, KK Bharani, L Mekala… - International …, 2022 - Elsevier
Acute lung injury (ALI) or acute respiratory distress syndrome (ARDS) is one of the leading
pulmonary inflammatory disorders causing significant morbidity and mortality. Vincamine is …

Unfractionated heparin ameliorates pulmonary microvascular endothelial barrier dysfunction via microtubule stabilization in acute lung injury

S Mu, Y Liu, J Jiang, R Ding, X Li, X Li, X Ma - Respiratory Research, 2018 - Springer
Background Endothelial barrier dysfunction is central to the pathogenesis of sepsis-
associated acute lung injury (ALI). Microtubule (MT) dynamics in vascular endothelium are …

Changes of lipopolysaccharide-induced acute kidney and liver injuries in rats based on metabolomics analysis

H Gao, T Yang, X Chen, Y Song - Journal of Inflammation …, 2021 - Taylor & Francis
Background The bacterial endotoxin lipopolysaccharide (LPS) was the classic inducer to
establish many inflammatory disease models, especially multiple organ injury. Evidences …

The anti-inflammatory potential of selected plant-derived compounds in respiratory diseases

J Wieczfinska, P Sitarek, T Kowalczyk… - Current …, 2020 - benthamdirect.com
Inflammation plays a major role in chronic airway diseases like asthma, COPD, and cystic
fibrosis. Inflammation plays a crucial role in the worsening of the lung function resulting in …