[HTML][HTML] Formate metabolism in health and disease
Background Formate is a one-carbon molecule at the crossroad between cellular and whole
body metabolism, between host and microbiome metabolism, and between nutrition and …
body metabolism, between host and microbiome metabolism, and between nutrition and …
Diseases Caused by Mutations in Mitochondrial Carrier Genes SLC25: A Review
In the 1980s, after the mitochondrial DNA (mtDNA) had been sequenced, several diseases
resulting from mtDNA mutations emerged. Later, numerous disorders caused by mutations …
resulting from mtDNA mutations emerged. Later, numerous disorders caused by mutations …
Combinatorial GxGxE CRISPR screen identifies SLC25A39 in mitochondrial glutathione transport linking iron homeostasis to OXPHOS
The SLC25 carrier family consists of 53 transporters that shuttle nutrients and co-factors
across mitochondrial membranes. The family is highly redundant and their transport …
across mitochondrial membranes. The family is highly redundant and their transport …
SLC25A32 promotes malignant progression of glioblastoma by activating PI3K-AKT signaling pathway
Z Xue, J Wang, Z Wang, J Liu, J Zhao, X Liu, Y Zhang… - BMC cancer, 2023 - Springer
Background Solute carrier family 25 member 32 (SLC25A32) is an important member of
SLC25A family and plays a role in folate transport metabolism. However, the mechanism …
SLC25A family and plays a role in folate transport metabolism. However, the mechanism …
Insights into the etiology of mammalian neural tube closure defects from developmental, genetic and evolutionary studies
DM Juriloff, MJ Harris - Journal of developmental biology, 2018 - mdpi.com
The human neural tube defects (NTD), anencephaly, spina bifida and craniorachischisis,
originate from a failure of the embryonic neural tube to close. Human NTD are relatively …
originate from a failure of the embryonic neural tube to close. Human NTD are relatively …
Mechanics of neural tube morphogenesis
LD Moon, F Xiong - Seminars in Cell & Developmental Biology, 2022 - Elsevier
The neural tube is an important model system of morphogenesis representing the
developmental module of out-of-plane epithelial deformation. As the embryonic precursor of …
developmental module of out-of-plane epithelial deformation. As the embryonic precursor of …
One-carbon metabolism and folate transporter genes: Do they factor prominently in the genetic etiology of neural tube defects?
Neural tube defects (NTDs) are a broad class of congenital birth defects that result from the
failure of neural tube closure during neurulation. Folic acid supplementation has been …
failure of neural tube closure during neurulation. Folic acid supplementation has been …
Mitochondria in early forebrain development: from neurulation to mid-corticogenesis
RM Fame, MK Lehtinen - Frontiers in Cell and Developmental Biology, 2021 - frontiersin.org
Function of the mature central nervous system (CNS) requires a substantial proportion of the
body's energy consumption. During development, the CNS anlage must maintain its …
body's energy consumption. During development, the CNS anlage must maintain its …
Mitochondrial folate pathway regulates myofibroblast differentiation and silica-induced pulmonary fibrosis
Y Qu, R Zhai, D Wang, Z Wang, G Hou, C Wu… - Journal of Translational …, 2023 - Springer
Background Silica-induced pulmonary fibrosis (silicosis) is a diffuse interstitial fibrotic
disease characterized by the massive deposition of extracellular matrix in lung tissue …
disease characterized by the massive deposition of extracellular matrix in lung tissue …
Gene–environment interactions underlying the etiology of neural tube defects
CD Caiaffa, CSR Fonteles, L Yunping… - Current Topics in …, 2023 - Elsevier
Neural tube defects (NTDs) consist of severe structural malformations of the brain and spinal
cord and are the second most common structural birth defect in humans, accounting for …
cord and are the second most common structural birth defect in humans, accounting for …