The phosphatidylinositol 3 kinase (PI3K) pathway is frequently altered in cancer, including
ovarian cancer (OC). Unfortunately, despite a sound biological rationale and encouraging …

Abstract Glycogen synthase kinase-3 (GSK-3) is a serine/threonine kinase that participates
in an array of critical cellular processes. GSK-3 was first characterized as an enzyme that …

The high recurrence rate and the low overall survival in ovarian cancer suggest that a more
specific therapeutic approach in addition to conventional treatment is required. Translational …

Epithelial ovarian cancer (EOC) is the leading cause of gynecologic cancer mortality
worldwide. Platinum-based therapy is the standard first line treatment and while most …

It is well established that obesity increases the incidence and worsens the prognosis of
women's cancer. For breast cancer, women with obesity exhibit more than a twofold …

Endometrioid carcinoma (EC) is a relatively indolent ovarian carcinoma subtype that is
nonetheless deadly if detected late. Existing genetically engineered mouse models …

Women with endometriosis are at increased risk of developing ovarian cancer, specifically
ovarian endometrioid, low-grade serous, and clear-cell adenocarcinoma. An important …

Epithelial ovarian cancer presents mostly with serous, endometrioid or mucinous histology
but is treated as a single disease. The development of histotype-specific therapy has been …

Inactivation of the ARID1A tumour suppressor gene is frequent in ovarian endometrioid
(OEC) and clear cell (OCCC) carcinomas, often in conjunction with mutations activating the …

Transcription factors (TFs) are major contributors to cancer risk and somatic development. In
preclinical and clinical studies, direct or indirect inhibition of TF-mediated oncogenic gene …