Mammary adipose tissue (AT) is necessary for breast epithelium. However, in breast cancer
(BC), cell-cell interactions are deregulated as the tumor chronically modifies AT …

The insulin-like growth factors (IGFs; IGF-1 and IGF-2) play central roles in cell growth,
differentiation, survival, transformation and metastasis. The biologic effects of the IGFs are …

Past studies have shown that amplified insulin-like growth factor 1 (IGF1)/IGF1 receptor
(IGF1-R) signalling has an important role in colorectal cancer (CRC) development …

Aims/hypothesis Type 2 diabetes and obesity are associated with increased risk of site-
specific cancers. We have investigated whether metabolic alterations at the level of adipose …

The nuclear receptor PPARγ is a key regulator of adipogenesis, and alterations of its
function are associated with different pathological processes related to metabolic syndrome …

MicroRNA let-7 has been reported to be down-regulated in several human cancers and is
now characterized as a tumor suppressor. IGF1R is over-expressed in many cancers and …

Genomic alterations (GA) in PIK3CA leads to the hyper-activation of the phosphatidylinositol-
4, 5-bisphosphate 3-kinase (PI3K) pathway in more than 20% of ovarian cancer (OC) …

Adipose tissue‐derived mesenchymal stem cells (Ad‐MSC) and platelet derivatives have
been used alone or in combination to achieve regeneration of injured tissues. We have …

Colon cancers develop adaptive mechanisms to survive under extreme conditions and
display hallmarks of unlimited proliferation and resistance to cell death. The deregulation of …

New therapeutic strategies are needed for colorectal cancer (CRC) treatment. MicroRNAs
are involved in cancer‑pertinent cellular processes, including chemoresistance. As miR …