Transposable elements in mammalian chromatin organization
Transposable elements (TEs) are mobile DNA elements that comprise almost 50% of
mammalian genomic sequence. TEs are capable of making additional copies of themselves …
mammalian genomic sequence. TEs are capable of making additional copies of themselves …
Activation of human endogenous retroviruses and its physiological consequences
Human endogenous retroviruses (HERVs) are abundant sequences that persist within the
human genome as remnants of ancient retroviral infections. These sequences became fixed …
human genome as remnants of ancient retroviral infections. These sequences became fixed …
Super-pangenome analyses highlight genomic diversity and structural variation across wild and cultivated tomato species
Effective utilization of wild relatives is key to overcoming challenges in genetic improvement
of cultivated tomato, which has a narrow genetic basis; however, current efforts to decipher …
of cultivated tomato, which has a narrow genetic basis; however, current efforts to decipher …
Evidence that direct inhibition of transcription factor binding is the prevailing mode of gene and repeat repression by DNA methylation
S Kaluscha, S Domcke, C Wirbelauer, MB Stadler… - Nature …, 2022 - nature.com
Cytosine methylation efficiently silences CpG-rich regulatory regions of genes and repeats
in mammalian genomes. To what extent this entails direct inhibition of transcription factor …
in mammalian genomes. To what extent this entails direct inhibition of transcription factor …
Evolutionary constraint and innovation across hundreds of placental mammals
Zoonomia is the largest comparative genomics resource for mammals produced to date. By
aligning genomes for 240 species, we identify bases that, when mutated, are likely to affect …
aligning genomes for 240 species, we identify bases that, when mutated, are likely to affect …
Pangenomic analysis identifies structural variation associated with heat tolerance in pearl millet
Pearl millet is an important cereal crop worldwide and shows superior heat tolerance. Here,
we developed a graph-based pan-genome by assembling ten chromosomal genomes with …
we developed a graph-based pan-genome by assembling ten chromosomal genomes with …
DNA methylation-free Arabidopsis reveals crucial roles of DNA methylation in regulating gene expression and development
L He, H Huang, M Bradai, C Zhao, Y You, J Ma… - Nature …, 2022 - nature.com
A contribution of DNA methylation to defense against invading nucleic acids and
maintenance of genome integrity is uncontested; however, our understanding of the extent …
maintenance of genome integrity is uncontested; however, our understanding of the extent …
Significantly improving the quality of genome assemblies through curation
K Howe, W Chow, J Collins, S Pelan, DL Pointon… - …, 2021 - academic.oup.com
Genome sequence assemblies provide the basis for our understanding of biology.
Generating error-free assemblies is therefore the ultimate, but sadly still unachieved goal of …
Generating error-free assemblies is therefore the ultimate, but sadly still unachieved goal of …
Ensembl Genomes 2022: an expanding genome resource for non-vertebrates
AD Yates, J Allen, RM Amode, AG Azov… - Nucleic acids …, 2022 - academic.oup.com
Abstract Ensembl Genomes (https://www. ensemblgenomes. org) provides access to non-
vertebrate genomes and analysis complementing vertebrate resources developed by the …
vertebrate genomes and analysis complementing vertebrate resources developed by the …
Optical maps refine the bread wheat Triticum aestivum cv. Chinese Spring genome assembly
Until recently, achieving a reference‐quality genome sequence for bread wheat was long
thought beyond the limits of genome sequencing and assembly technology, primarily due to …
thought beyond the limits of genome sequencing and assembly technology, primarily due to …