The spliceosome: disorder and dynamics defined
W Chen, MJ Moore - Current opinion in structural biology, 2014 - Elsevier
Highlights•Evolutionarily young spliceosomal proteins have high intrinsic
disorder.•Spliceosome assembly is reversible and can occur by multiple …
disorder.•Spliceosome assembly is reversible and can occur by multiple …
Structure determination and dynamics of protein–RNA complexes by NMR spectroscopy
As of March 2010, 141 structures of protein–RNA complexes with a molecular weight lower
than 40 kDa have been deposited in the Protein Data Bank (PDB). Of these structures, 52 …
than 40 kDa have been deposited in the Protein Data Bank (PDB). Of these structures, 52 …
One, two, three, four! How multiple RRMs read the genome sequence
RRM-containing proteins are involved in most of the RNA metabolism steps. Their functions
are closely related to their mode of RNA recognition, which has been studied by structural …
are closely related to their mode of RNA recognition, which has been studied by structural …
Crystal structures of the Lsm complex bound to the 3′ end sequence of U6 small nuclear RNA
Splicing of precursor messenger RNA (pre-mRNA) in eukaryotic cells is carried out by the
spliceosome, which consists of five small nuclear ribonucleoproteins (snRNPs) and a …
spliceosome, which consists of five small nuclear ribonucleoproteins (snRNPs) and a …
Core structure of the U6 small nuclear ribonucleoprotein at 1.7-Å resolution
EJ Montemayor, EC Curran, HH Liao… - Nature structural & …, 2014 - nature.com
The spliceosome is a dynamic assembly of five small nuclear ribonucleoproteins (snRNPs)
that removes introns from eukaryotic pre-mRNA. U6, the most conserved of the spliceosomal …
that removes introns from eukaryotic pre-mRNA. U6, the most conserved of the spliceosomal …
Solution structure of the two RNA recognition motifs of hnRNP A1 using segmental isotope labeling: how the relative orientation between RRMs influences the nucleic …
P Barraud, FHT Allain - Journal of biomolecular NMR, 2013 - Springer
Human hnRNP A1 is a multi-functional protein involved in many aspects of nucleic-acid
processing such as alternative splicing, micro-RNA biogenesis, nucleo-cytoplasmic mRNA …
processing such as alternative splicing, micro-RNA biogenesis, nucleo-cytoplasmic mRNA …
Structural insight into RNA recognition motifs: versatile molecular Lego building blocks for biological systems
Y Muto, S Yokoyama - Wiley Interdisciplinary Reviews: RNA, 2012 - Wiley Online Library
Abstract 'RNA recognition motifs (RRMs)'are common domain‐folds composed of 80–90
amino‐acid residues in eukaryotes, and have been identified in many cellular proteins. At …
amino‐acid residues in eukaryotes, and have been identified in many cellular proteins. At …
Structural basis for the dual RNA-recognition modes of human Tra2-β RRM
K Tsuda, T Someya, K Kuwasako… - Nucleic acids …, 2011 - academic.oup.com
Abstract Human Transformer2-β (hTra2-β) is an important member of the serine/arginine-
rich protein family, and contains one RNA recognition motif (RRM). It controls the alternative …
rich protein family, and contains one RNA recognition motif (RRM). It controls the alternative …
From structure to function of RNA binding domains
RNAtoare specific composed binding RNA proteins of small targets.(RBPs) RNA The
binding are mode involved of domains RNA in each recognition (RBDs) step that of RNA of …
binding are mode involved of domains RNA in each recognition (RBDs) step that of RNA of …
U6 RNA biogenesis and disease association
S Mroczek, A Dziembowski - Wiley Interdisciplinary Reviews …, 2013 - Wiley Online Library
U6 snRNA is one of five uridine‐rich noncoding RNAs that form the major spliceosome
complex. Unlike other U‐snRNAs, it reveals many distinctive aspects of biogenesis such as …
complex. Unlike other U‐snRNAs, it reveals many distinctive aspects of biogenesis such as …