Intestinal fibrosis in inflammatory bowel disease and the prospects of mesenchymal stem cell therapy

Y Wang, B Huang, T Jin, DKW Ocansey… - Frontiers in …, 2022 - frontiersin.org
Intestinal fibrosis is an important complication of inflammatory bowel disease (IBD). In the
course of the development of fibrosis, certain parts of the intestine become narrowed …

Novel mechanisms and clinical trial endpoints in intestinal fibrosis

J Wang, S Lin, JM Brown, D van Wagoner… - Immunological …, 2021 - Wiley Online Library
The incidence of inflammatory bowel diseases (IBD) worldwide has resulted in a global
public health challenge. Intestinal fibrosis leading to stricture formation and bowel …

Results of the Seventh Scientific Workshop of ECCO: Precision medicine in IBD—disease outcome and response to therapy

B Verstockt, NM Noor, UM Marigorta… - Journal of Crohn's …, 2021 - academic.oup.com
Inflammatory bowel diseases [IBD] are a heterogeneous spectrum with two extreme
phenotypes, Crohn's disease [CD] and ulcerative colitis [UC], which both represent …

Fibrosis in IBD: from pathogenesis to therapeutic targets

F Rieder, PK Mukherjee, WJ Massey, Y Wang… - Gut, 2024 - gut.bmj.com
Background Intestinal fibrosis resulting in stricture formation and obstruction in Crohn's
disease (CD) and increased wall stiffness leading to symptoms in ulcerative colitis (UC) is …

Biomarkers for the prediction and diagnosis of fibrostenosing Crohn's disease: a systematic review

CA Steiner, JA Berinstein, J Louissaint… - Clinical …, 2022 - Elsevier
Background and Aims Intestinal strictures are a common complication of Crohn's disease
(CD). Biomarkers of intestinal strictures would assist in their prediction, diagnosis, and …

Recent advances in intestinal fibrosis

MV Lenti, G Santacroce, G Broglio, CM Rossi… - Molecular Aspects of …, 2024 - Elsevier
Despite many progresses have been made in the treatment of inflammatory bowel disease,
especially due to the increasing number of effective therapies, the development of tissue …

Fibronectin has multifunctional roles in posterior capsular opacification (PCO)

MH Shihan, M Kanwar, Y Wang, EE Jackson… - Matrix Biology, 2020 - Elsevier
Fibrotic posterior capsular opacification (PCO), one of the major complications of cataract
surgery, occurs when lens epithelial cells (LCs) left behind post cataract surgery (PCS) …

Big data in gastroenterology research

M Alizadeh, N Sampaio Moura, A Schledwitz… - International Journal of …, 2023 - mdpi.com
Studying individual data types in isolation provides only limited and incomplete answers to
complex biological questions and particularly falls short in revealing sufficient mechanistic …

[HTML][HTML] Multi-omics in Crohn's disease: New insights from inside

C Mu, Q Zhao, Q Zhao, L Yang, X Pang, T Liu… - Computational and …, 2023 - Elsevier
Crohn's disease (CD) is an inflammatory bowel disease (IBD) with complex clinical
manifestations such as chronic diarrhea, weight loss and hematochezia. Despite the …

How to evaluate fibrosis in IBD?

H Tavares de Sousa, F Magro - Diagnostics, 2023 - mdpi.com
In this review, we will describe the importance of fibrosis in inflammatory bowel disease
(IBD) by discussing its distinct impact on Crohn's disease (CD) and ulcerative colitis (UC) …