Highlights•Addresses the nature of the distinction between bacterial transcription factors and
nucleoid-associated proteins.•Proteins lie along a spectrum of influence extending from …

Transcription activation is an important checkpoint of regulation of gene expression which
occurs in response to different intracellular and extracellular signals. The key elements in …

Dear Editor, CRISPR-Cas systems provide adaptive immunity in prokaryotes through RNA-
guided cleavage of mobile genetic elements and have been harnessed as powerful genome …

Streptomycetes are filamentous bacteria that differentiate by producing spore-bearing
reproductive structures called aerial hyphae. The transition from vegetative to reproductive …

HrdB in streptomycetes is a principal sigma factor whose deletion is lethal. This is also the
reason why its regulon has not been investigated so far. To overcome experimental …

Hfq regulates bacterial gene expression post-transcriptionally by binding small RNAs and
their target mRNAs, facilitating sRNA-mRNA annealing, typically resulting in translation …

The MerR family of transcriptional regulators includes a variety of bacterial cytoplasmic
proteins that respond to a wide range of signals, including toxins, metal ions, and …

Streptomyces coelicolor and Streptomyces lividans constitute model strains to study the
regulation of antibiotics biosynthesis in Streptomyces species since these closely related …

For decades, natural products have been used as a primary resource in drug discovery
pipelines to find new antibiotics, which are mainly produced as secondary metabolites by …

Pathogenic bacteria encounter host-imposed manganese (Mn) limitation during infection.
Herein we report that in the human pathogen Streptococcus pyogenes, the adaptive …